IMF, ECB and Others Give 2022 Economic Outlook Today

from the World Economic Forum Davos Agenda:

Today the IMF, European Central Bank, and global economic leaders discussed the future of the economy at the “Global Economic Outlook” session at Davos Agenda 2022.

Inflation, global economic recovery and COVID-19 impacts are discussed.

Please find selected quotes below. View the full session here.

Christine Lagarde, President, European Central Bank:

“In Europe, we are not seeing inflation spiral out of control. We assume energy prices will stabilize from the middle of 2022, bottlenecks will also stabilize in 2022 and gradually, inflation numbers will decline.”

“When I look at the labor market, we are not experiencing anything like The Great Resignation, and our employment participation numbers are getting very close to the pre-pandemic level.”

“In Europe we are unlikely to face the kind of inflation increases that the U.S. market has faced.”

“More recently, we have learnt the lesson of humility–the ECB, IMF, OECD and others all underestimated the recovery, the employment participation and, obviously, inflation.”

Kristalina Georgieva, Managing Director, International Monetary Fund (IMF):

“The response to the pandemic crisis has been anything but orthodox— in a highly coordinated manner both central banks and finance authorities have prevented the world falling into yet another great depression.”

“If I were to offer policy makers a new year’s resolution, it would policy flexibility.”

“In low-income countries, 60% are in either debt distress or in danger of debt distress–more than twice as many as in 2015.”

Haruhiko Kuroda (黒田 東彦), Governor, Bank of Japan:

Japan response to the pandemic has been relatively successful, however, the pandemic has had a significant, negative impact on Japan’s economy.”

“Unlike U.S. or Europe, we have to continue extremely accommodative, easy monetary policy for the time being. We expect the inflation rate in 2022 and 2023 to be around 1 percent still.”

Paulo Guedes, Minister of Economy, Ministry of Economy of Brazil:

Central banks are sleeping at the wheel–inflation will be a real problem very soon for the western world.”

“More than 3 million new jobs were created in 2021 and the government has assisted 68 million Brazilians with direct income transfers.”

Sri Mulyani Indrawati, Minister of Finance, Ministry of Finance of Indonesia

“We see a strong recovery in the Indonesian economy in 2022, and to build on this we are expecting more than 1% of additional GDP growth from a series of recent reforms.”

Indonesia is the largest economy in the ASEAN region, but it is vulnerable to a dependence on commodities–the emphasis now is on value-added activities.”

About the Davos Agenda 2022

For over 50 years, the World Economic Forum has been the international organization for public-private cooperation. The Davos Agenda 2022 is the focal point at the start of the year for leaders to share their outlook, insights and plans relating to the most urgent global issues. The meeting will provide a platform to accelerate the partnerships needed to tackle shared challenges and shape a more sustainable and inclusive future. Learn more about the program and view sessions live and on demand.

Pathogens-Watching

New Articles in PLOS Pathogens

Insertive Condom-Protected and Condomless Vaginal Sex Both Have a Profound Impact on the Penile Immune Correlates of HIV Susceptibility

by Avid Mohammadi, Sareh Bagherichimeh, Yoojin Choi, Azadeh Fazel, Elizabeth Tevlin, Sanja Huibner, Zhongtian Shao, David Zuanazzi, Jessica L. Prodger, Sara V. Good, Wangari Tharao & Rupert Kaul

Summary: In heterosexual men, the penis is the primary site of Human Immunodeficiency Virus (HIV) acquisition. Levels of inflammatory cytokines in the coronal sulcus are associated with an increased HIV risk, and we hypothesized that these may be altered after insertive penile sex. Therefore, we designed the Sex, Couples and Science Study (SECS study) to define the impact of penilevaginal sex on the penile immune correlates of HIV susceptibility. We found that multiple coronal sulcus cytokines increased dramatically and rapidly after sex, regardless of condom use, with a return to baseline levels by 72 hours. The changes observed after condomless sex were strongly predicted by cytokine concentrations in the vaginal secretions of the female partner, and were similar in circumcised and uncircumcised men. We believe that these findings have important implications for understanding the immunopathogenesis of penile HIV acquisition; in addition, they have important implications for the design of clinical studies of penile HIV acquisition and prevention.

[Archived PDF]

Engineering, Decoding and Systems-Level Characterization of Chimpanzee Cytomegalovirus

by Quang Vinh Phan, Boris Bogdanow, Emanuel Wyler, Markus Landthaler, Fan Liu, Christian Hagemeier & Lüder Wiebusch

Summary: Human cytomegalovirus (HCMV) infection is associated with systemic disease in immunocompromised individuals and congenitally infected neonates. Animal CMVs and their bacterial artificial chromosome (BAC) clones have been utilized as models for CMV infection and thereby contributed immensely to the understanding of pathogenesis, host immune response and underlying molecular mechanism of CMV infections. As the closest relative to HCMV, the chimpanzee CMV (CCMV) holds a great potential as a model system for HCMV infection but its application was limited due to the lack of tools and data for functional genomic analyses. Here, the cloning of the CCMV as a BAC vector made its viral genome available to gene targeting techniques that allow the efficient application of reverse genetic strategies. Furthermore, the multi-omic datasets created in this study provide an in-depth view of the viral gene repertoire and the host cell responses to infection, confirming the close phylogenetic relationship between HCMV and CCMV on a system level. Taken together, the newly established CCMVBAC system presents a framework for HCMV modeling and comparative studies to address key questions in evolutionary processes and infection mechanisms.

[Archived PDF]

RplI Interacts with 5′ UTR of exsA to Repress Its Translation and Type III Secretion System in Pseudomonas aeruginosa

by Dan Wang, Xinxin Zhang, Liwen Yin, Qi Liu, Zhaoli Yu, Congjuan Xu, Zhenzhen Ma, Yushan Xia, Jing Shi, Yuehua Gong, Fang Bai, Zhihui Cheng, Weihui Wu, Jinzhong Lin & Yongxin Jin

Summary: Ribosomes provide all living organisms the capacity to synthesize proteins. The production of many ribosomal proteins is often controlled by an autoregulatory feedback mechanism. Paeruginosa is an opportunistic human pathogen and its type III secretion system (T3SS) is a critical virulence determinant in host infections. In this study, by screening a Tn5 mutant library, we identified rplI, encoding ribosomal large subunit protein L9, as a novel repressor for the T3SS. Further exploring the regulatory mechanism, we found that the RplI protein interacts with the 5’ UTR (5’ untranslated region) of exsA, a gene coding for transcriptional activator of the T3SS. Such an interaction likely blocks ribosome loading on the exsA 5’ UTR, inhibiting the initiation of exsA translation. The significance of this work is in the identification of a novel repressor for the T3SS and elucidation of its molecular mechanism. Furthermore, this work provides evidence for individual ribosomal protein regulating mRNA translation beyond its autogenous feedback control.

[Archived PDF]

Structure of a Bacterial Rhs Effector Exported by the Type VI Secretion System

by Patrick Günther, Dennis Quentin, Shehryar Ahmad, Kartik Sachar, Christos Gatsogiannis, John C. Whitney & Stefan Raunser

Summary: Bacteria have developed a variety of strategies to compete for nutrients and limited resources. One system widely used by Gram-negative bacteria is the T6 secretion system which delivers a plethora of effectors into competing bacterial cells. Known functions of effectors are degradation of the cell wall, the depletion of essential metabolites such as NAD+ or the cleavage of DNA. RhsA is an effector from the widespread plant-protecting bacteria Pseudomonas protegens. We found that RhsA forms a closed cocoon similar to that found in bacterial Tc toxins and metazoan teneurin proteins. The effector cleaves its polypeptide chain by itself in three pieces, namely the N-terminal domain including a seal, the cocoon and the actual toxic component which potentially cleaves DNA. The toxic component is encapsulated in the large cocoon, so that the effector producing bacterium is protected from the toxin. In order for the toxin to exit the cocoon, we propose that the seal, which closes the cocoon at one end, is removed by mechanical forces during injection of the effector by the T6 secretion system. We further hypothesize about different scenarios for the delivery of the toxin into the cytoplasm of the host cell. Together, our findings expand the knowledge of the mechanism of action of the T6 secretion system and its essential role in interbacterial competition.

[Archived PDF]

Non-Neutralizing Antibodies Targeting the Immunogenic Regions of HIV-1 Envelope Reduce Mucosal Infection and Virus Burden in Humanized Mice

by Catarina E. Hioe, Guangming Li, Xiaomei Liu, Ourania Tsahouridis, Xiuting He, Masaya Funaki, Jéromine Klingler, Alex F. Tang, Roya Feyznezhad, Daniel W. Heindel, Xiao-Hong Wang, David A. Spencer, Guangnan Hu, Namita Satija, Jérémie Prévost, Andrés Finzi, Ann J. Hessell, Shixia Wang, Shan Lu, Benjamin K. Chen, Susan Zolla-Pazner, Chitra Upadhyay, Raymond Alvarez & Lishan Su

Summary: In the past decade, HIV-1 has infected an estimated 1.5 to 2 million people every year, but vaccines needed to control this pandemic are unavailable. Among vaccines tested in the human efficacy trials, the RV144 vaccine regimen showed a modest efficacy and revealed non-neutralizing antibodies against the virus envelope glycoproteins as a correlate of reduced virus acquisition. To design more efficacious HIV-1 vaccines, a better understanding about antiviral mechanisms of these antibodies is needed. Here non-neutralizing monoclonal antibodies against two immunogenic sites on the virus envelope were evaluated for passive administration to humanized mice that were subsequently challenged with HIV-1. The antibodies did not block mucosal HIV-1 infection but reduced virus burden. The level of virus reduction correlated with the antibody binding potency and the effector functions mediated through their Fc fragments, which included antibody-dependent phagocytosis and complement activation, but not the commonly studied antibody-dependent cellular cytotoxicity. The importance of the Fc functions was further demonstrated by reduced virus control when mutations were introduced to decrease Fc activities. This study provides new evidence for the important contribution of multiple Fc-dependent antibody functions in immune control against HIV-1.

[Archived PDF]

Variability in an Effector Gene Promoter of a Necrotrophic Fungal Pathogen Dictates Epistasis and Effector-Triggered Susceptibility in Wheat

by Evan John, Silke Jacques, Huyen T. T. Phan, Lifang Liu, Danilo Pereira, Daniel Croll, Karam B. Singh, Richard P. Oliver & Kar-Chun Tan

Summary: Breeding for durable resistance to fungal diseases in crops is a continual challenge for crop breeders. Fungal pathogens evolve ways to overcome host resistance by masking themselves through effector evolution and evasion of broad-spectrum defense responses. Association studies on mapping populations infected by isolate mixtures are often used by researchers to seek out novel sources of genetic resistance. Disease resistance quantitative trait loci (QTL) are often minor or inconsistent across environments. This is a particular problem with septoria diseases of cereals such as septoria nodorum blotch (SNB) of wheat caused by Parastagonospora nodorum. The fungus uses a suite of necrotrophic effectors (NEs) to cause SNB. We characterized a genetic element, called PE401, in the promoter of the major NE gene Tox1, which is present in some Pnodorum isolates. PE401 functions as a transcriptional repressor of Tox1 and exerts epistatic control on another major SNB resistance QTL in the host. In the context of crop protection, constant surveillance of the pathogen population for the frequency of PE401 in conjunction with NE diversity will enable agronomists to provide the best advice to growers on which wheat varieties can be tailored to provide optimal SNB resistance to regional pathogen population genotypes.

[Archived PDF]

Mutational Analysis of Aedes aegypti Dicer 2 Provides Insights into the Biogenesis of Antiviral Exogenous Small Interfering RNAs

by Rommel J. Gestuveo, Rhys Parry, Laura B. Dickson, Sebastian Lequime, Vattipally B. Sreenu, Matthew J. Arnold, Alexander A. Khromykh, Esther Schnettler, Louis Lambrechts, Margus Varjak & Alain Kohl

Summary: Aedes aegypti mosquitoes that transmit human-pathogenic viruses rely on the exogenous small interfering RNA (exo-siRNA) pathway as part of antiviral responses. This pathway is triggered by virus-derived double-stranded RNA (dsRNA) produced during viral replication that is then cleaved by Dicer 2 (Dcr2) into virus-derived small interfering RNAs (vsiRNAs). These vsiRNAs target viral RNA, leading to suppression of viral replication. The importance of Dcr2 in this pathway has been intensely studied in the Drosophila melanogaster model but is largely lacking in mosquitoes. Here, we have identified conserved and functionally relevant amino acids in the helicase and RNase III domains of Aeaegypti Dcr2 that are important in its silencing activity and antiviral responses against Semliki Forest virus (SFV). Small RNA sequencing of SFV-infected mosquito cells with functional or mutated Dcr2 gave new insights into the nature and origin of vsiRNAs. The findings of this study, together with the different molecular tools we have previously developed to investigate the exo-siRNA pathway of mosquito cells, have started to uncover important properties of Dcr2 that could be valuable in understanding mosquito-arbovirus interactions and potentially in developing or assisting vector control strategies.

[Archived PDF]

Probing the Structure and Function of the Protease Domain of Botulinum Neurotoxins Using Single-Domain Antibodies

by Kwok-ho Lam, Jacqueline M. Tremblay, Kay Perry, Konstantin Ichtchenko, Charles B. Shoemaker & Rongsheng Jin

Summary: Botulinum neurotoxins (BoNTs) are extremely toxic to humans by causing flaccid paralysis of botulism. The catalytic light chain (LC) of BoNTs is the warhead of the toxin, which is mainly responsible for BoNT’s neurotoxic effects. As an endopeptidase, LC is delivered by the toxin to inside neurons where it specifically cleaves neuronal SNARE proteins and causes muscle paralysis. While the currently available equine and human antitoxin sera can prevent further intoxication, they do not promote recovery from paralysis that has already occurred. We strike to develop single-domain variable heavy-chain (VHH) antibodies targeting the LC of BoNT/A (LC/A) and BoNT/B (LC/B) as antidotes to inhibit or eliminate the intraneuronal LC protease. Here, we report the identification and characterization of large panels of new and unique VHHs that bind to LC/A or LC/B. Using a combination of X-ray crystallography and biochemical assays, we reveal that VHHs exploit diverse mechanisms to interact with LC/A and LC/B and inhibit their protease activity, and such knowledge can be harnessed to predict their specificity towards different toxin subtypes within each serotype. We anticipate that the new VHHs and their characterization reported here will contribute to the development of improved botulism therapeutics having high potencies and broad specificities.

[Archived PDF]

B Cell Overexpression of FCRL5 and PD-1 Is Associated with Low Antibody Titers in HCV Infection

by Clinton O. Ogega, Nicole E. Skinner, Andrew I. Flyak, Kaitlyn E. Clark, Nathan L. Board, Pamela J. Bjorkman, James E. Crowe Jr., Andrea L. Cox, Stuart C. Ray & Justin R. Bailey

Summary: Antiviral immunity relies on production of protective immunoglobulin G (IgG) by B cells, but many hepatitis C virus (HCV)-infected individuals have very low levels of HCV-specific IgG in their serum. Elucidating mechanisms underlying this suboptimal IgG expression remains paramount in guiding therapeutic and vaccine strategies. In this study, we developed a highly specific method to capture HCV-specific B cells and characterized their surface protein expression. Two proteins analyzed were Fc receptor-like protein 5 (FCRL5), a cell surface receptor for IgG, and programmed cell death protein-1 (PD-1), a marker of lymphocyte activation and exhaustion. We measured serum levels of anti-HCV IgG in these subjects and demonstrated that overexpression of FCRL5 and PD-1 on memory B cells was associated with reduced anti-E2 IgG levels. This study uses HCV as a viral model, but the findings may be applicable to many viral infections, and they offer new potential targets to enhance antiviral IgG production.

[Archived PDF]

Following COVID-19 Evolution Carefully

JAMA Online First: Booster Vaccination to Reduce SARS-CoV-2 Infection

Association of a Third Dose of BNT162b2 Vaccine With Incidence of SARS-CoV-2 Infection Among Health Care Workers in Israel

by Avishay Spitzer, MD; Yoel Angel, MD, MBA; Or Marudi, MSc; et al.

[Archived PDF]

Editorial: Booster Vaccination to Reduce SARS-CoV-2 Transmission and Infection by Anna Wald, MD, MPH

[Archived PDF]

A National Strategy for the “New Normal” of Life With COVID

[Archived PDF]

False-Positive Results in Rapid Antigen Tests for SARS-CoV-2

[Archived PDF]

Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave

[Archived PDF]

Highlights From the American Heart Association’s Scientific Sessions—ApoB as a Risk Marker, an Oral PCSK9 Inhibitor, Aspirin and Dementia, and More

[Archived PDF]

India-Watching

ICRIER Working Paper № 407

India’s Platform Economy and Emerging Regulatory Challenges

by Rajat Kathuria, Mansi Kedia and Kaushambi Bagchi

Abstract

The phenomenal rise of the platform economy has reshaped how economies operate across the world. The importance of digital platforms has never been more evident than in combatting the ongoing coronavirus (COVID-19) pandemic. Even with the threat of a global recession looming large, technology companies are witnessing a surge in demand for their services. Platforms distinguish themselves from traditional markets by demonstrating speed and scale of innovation and fostering efficient and productive interaction between buyers and sellers. Enterprises using platform-based business models have expanded beyond social media, travel and entertainment to sectors like financial services, healthcare, logistics and transportation. With the objective of building evidence for policy-making in this sector, this study undertakes an in-depth analysis of the impact generated by the platform economy in India, by estimating consumer surplus from the use of platforms, analyzing its impact on traditional businesses either by transformation or disruption. The estimated consumer surplus is Rs. 438.75 per individual per month, amounting to a collective annual surplus of Rs. 3620 billion for India. At current exchange rates this would amount to $47 billion. 

The growth of platforms has also been accompanied by global concern against their anti-competitive practices, the spread of fake news and harmful content, political bias, etc. The paper discusses regulatory changes and areas of concern for market competition, labour and employment, fake news and misinformation, consumer protection, counterfeit goods and data privacy in India.

[Read full article, archived PDF]

[Executive summary, archived PDF]

Sustainable Development Goals: Their Impacts on Forests and People (New Book)

(from the Forest Policy Info Mailing List and IUFRO WFSE)

By Dr. Pia Katila

Forests provide vital ecosystem services crucial to human well-being and sustainable development, and have an important role to play in achieving the seventeen Sustainable Development Goals (SDGs) of the United Nations 2030 Agenda. Little attention, however, has yet focused on how efforts to achieve the SDGs will impact forests and forest-related livelihoods, and how these impacts may, in turn, enhance or undermine the contributions of forests to climate and development. Understanding the potential impacts of SDGs on forests and forest-related livelihoods and development as well as the related trade-offs and synergies is crucial for the efforts undertaken to reach these goals. It is especially important for reducing potential negative impacts and to leverage opportunities to create synergies that will ultimately determine whether comprehensive progress towards the SDGs will be made.

This book discusses the conditions that influence how SDGs are implemented and prioritized, and provides a systematic, multidisciplinary global assessment of interlinkages among the SDGs and their targets, increasing understanding of potential synergies and unavoidable trade-offs between goals from the point of view of forests and people. Ideal for academic researchers, students and decision-makers interested in sustainable development in the context of forests, this book will provide invaluable knowledge for efforts to reach the SDGs

The assessment was undertaken by the International Union of Forest Research Organization’s Special Project World Forests, Society and Environment (IUFRO WFSE). It involved 120 scientists and experts from 60 different universities and research and development institutions as well as 38 scientists who acted as peer reviewers of the different SDG chapters. The development and publication of the book and policy brief were made possible by the financial contributions of the Ministry for Foreign Affairs of Finland and the Natural Resources Institute Finland.

The book is published by Cambridge University Press and available as open access via Cambridge Core.

Read the book [Archived PDF].

Read the related Policy Brief Harnessing forests for the Sustainable Development Goals: Building synergies and mitigating trade-offs [Archived PDF].

Essay 104: Economics—A Decade after the Global Recession: Lessons and Challenges for Emerging and Developing Economies

from M. Ayhan Kose, Director, Prospects Group, World Bank Group:

Dear Colleagues.

This year marks the tenth anniversary of the 2009 global recession. Most emerging market and developing economies (EMDEs) weathered the global recession relatively well, in part by using the sizeable fiscal and monetary policy buffers accumulated during the prior years of strong growth. However, a short-lived rebound in activity has been followed by a decade of protracted weakness in EMDEs amid bouts of financial market stress, falling commodity prices, and subdued trade and investment.

Are EMDEs ready to face a deeper global downturn, if it materializes? Our new study A Decade After the Global Recession: Lessons and Challenges for Emerging and Developing Economies [PDF] takes on this question. It examines developments of the past decade, draws lessons for these economies, and discusses policy options. The study is the first comprehensive analysis on the topic with a truly EMDE focus. It offers three main conclusions. First, perhaps for the first time, many EMDEs were able to implement large-scale countercyclical fiscal and monetary policy stimulus during the last global recession. Second, looking ahead, policymakers in many EMDEs are now equipped with stronger policy frameworks than in earlier global downturns or financial crises. Third, EMDEs have now less policy room to face a global downturn than they had before the 2009 global recession. Irrespective of the timing of the next global downturn, the big lesson of the past decade for EMDEs is clear: since they are less well prepared today than prior to the 2009 episode, they urgently need to undertake cyclical and structural policy measures to be able to effectively confront the next downturn when it happens.

You can download the book here [PDF]. Its table of contents is below (each chapter individually downloadable). All charts featured in the book (with underlying data series) are also available below.

A Decade After the Global Recession: Lessons and Challenges for Emerging and Developing Economies [PDF]

Edited by M. Ayhan Kose and Franziska Ohnsorge

Part I: Context

Chapter 1: A Decade After the Global Recession: Lessons and Challenges [PDF]
Chapter 2: What Happens During Global Recessions? [PDF]

Part II: In the Rearview Mirror

Chapter 3: Macroeconomic Developments [PDF]
Chapter 4: Financial Market Developments [PDF]
Chapter 5: Macroeconomic and Financial Sector Policies [PDF]

Part III: Looking Ahead

Chapter 6: Prospects, Risks, and Vulnerabilities [PDF]
Chapter 7: Policy Challenges [PDF]

Part IV: Implications for the World Bank Group

Chapter 8: The Role of the World Bank Group [PDF]

Excel Charts

Complete archive [ZIP]

Chapter 1 [XLSX]
Chapter 2 [XLSX]
Chapter 3 [XLSX]
Chapter 4 [XLSX]
Chapter 5 [XLSX]
Chapter 6 [XLSX] Box [XLSX]
Chapter 7 [XLSX]
Chapter 8 [XLSX]

PS: This study follows on the World Bank Group’s recent book on Inflation in Emerging and Developing Economies. For their main periodical products, please visit: Global Economic Prospects and Commodity Markets Outlook. For their full menu of monitoring publications, please visit: World Bank Economic Monitoring. For their analytical work on topical policy issues, please visit Prospects Group Policy Research Working Papers.

Essay 101: Science-Watching: Nature Contents: 21 November 2019

From Nature:

Editorial

Researchers Must Unite Against U.S. Environment Agency’s Attack on Scientific Evidence

[Archived PDF]

Human Germline Editing Needs One Message

[Archived PDF]

How California Can Use Its Research Muscle To Keep the Lights On

[Archived PDF]

World View

Stop the Science Training That Demands ‘Don’t Ask’

Jerry Ravetz

[Archived PDF]

News Round-Up

Hong Kong Violence, Deadly Bushfires and an Asteroid Farewell

[Archived PDF]

News

Rare Bird’s Detection Highlights Promise of ‘Environmental DNA’ 

Dyani Lewis

[Archived PDF]

Italy’s Plan to Create €300-Million Research Agency Draws Fire

Marta Paterlini

[Archived PDF]

‘Make Ebola a Thing of the Past’: First Vaccine Against Deadly Virus Approved

Ewen Callaway

[Archived PDF]

A Whole New World: Astronomers Draw First Global Map of Titan

Jonathan O’Callaghan

[Archived PDF]

Every Butterfly in the United States and Canada Now Has a Genome Sequence

Ewen Callaway

[Archived PDF]

Features

The Science Institutions Hiring Integrity Inspectors To Vet Their Papers

Alison Abbott

[Archived PDF]

How Two Intruders From Interstellar Space Are Upending Astronomy

Alexandra Witze

[Archived PDF]

Multimedia

Nature Podcast 21 November 2019

This week, an antibiotic that targets difficult-to-treat bacteria, and a roundup of the latest science news.

[Archived MP3]

Book Review

How We Probe and Pollute the Cosmos

Meg Urry

[Archived PDF]

How Stigma Subverts Public Health

Julie Pulerwitz

[Archived PDF]

The Art of Rest, Hive Minds, and Traversing Canada: Books in Brief

Andrew Robinson

[Archived PDF]

Comment

Disaster-Zone Research Needs a Code of Conduct

JC Gaillard & Lori Peek

[Archived PDF]

Feature

A Message for Mentors From Dissatisfied Graduate Students

Chris Woolston

[Archived PDF]

Technology Feature

Got Mutation? ‘Base Editors’ Fix Genomes One Nucleotide at a Time

Sandeep Ravindran

[Archived PDF]

Where I Work

Engineering a Dream Workspace

Kendall Powell

[Archived PDF]

Essay 99: Economics—Apple Card’s Fintech Problem; Improving AI-Based Recommendations; IBM & Nazi Germany

from Harvard Business School Working Knowledge:

Gender Bias Complaints against Apple Card Signal a Dark Side to Fintech

The possibility that Apple Card applicants were subject to gender bias opens a new frontier for the financial services sector in which regulators are largely absent, argues Karen Mills.

It’s No Joke: AI Beats Humans at Making You Laugh

New research shows people don’t trust recommendations made by machines—and that’s a problem for marketers who increasingly rely on AI-based technology to persuade consumers. Michael H. Yeomans explains how businesses can overcome that bias.

Do TV Debates Sway Voters?

As Democratic presidential candidates prepare for another debate, Vincent Pons reports that TV forums don’t influence voters.

Lessons from IBM in Nazi Germany

Geoffrey Jones discusses his case study, “Thomas J. Watson, IBM and Nazi Germany,” exploring the options and responsibilities of multinationals with investments in politically reprehensible regimes.

For Better Ideas, Bring the Right People to the Brainstorm

Better ideas emerge when extroverts and people open to new experiences put their heads together, according to research by Rembrand M. Koning. But what about introverts?

Should Non-Compete Clauses Be Abolished?

Non-compete clauses prevent workers from bringing secrets with them to competitors. But increasingly NCCs are unnecessarily restricting job mobility for low-level employees. Should they be banned? asks James Heskett.

Design Rules, Volume 2: How Technology Shapes Organizations series

Working papers by Carliss Y. Baldwin and Kim B. Clark explain how and why different types of technology design pose different opportunities and challenges for organizations and can become vital forces of innovation.

Essay 98: Economics—Policy Options: Increase Tax Rates on Capital Gains & Dividends

from Penn Wharton (University of Pennsylvania) Budget Model:

Policy Options: Increase Tax Rates on Capital Gains & Dividends

We estimate the budgetary and economic effects of increasing the top rate on long-term capital gains and qualified dividends from 20 percent to 24.2 percent, which is enacted on January 1st, 2021. We project that it will raise around $60 billion of additional revenue on a conventional basis over the 10-year budget window and increase GDP by 0.1 percent by 2050. [Archived PDF]