Tag: Columbia University

Science-Watching: New Insights into Polyamorphism Could Influence How Drugs Are Formulated

[from the Royal Society of Chemistry’s Chemistry World, by Patrick de Jongh]

Results from a study combining experiments and simulations could overturn the assumption that amorphous forms of the same compound have the same molecular arrangement. The team behind the work claims to have prepared three amorphous forms of the diuretic drug hydrochlorothiazide and determined that they have distinct properties and distinct types of disorder. ‘If polyamorphism is proved in the future to be a universal—or at least not a very rare—phenomenon, then the pharmaceutical industry will need to make screens for polyamorphism and this will also be an opportunity for patenting,’ comments Inês Martins, from the University of Copenhagen in Denmark, who led the work with Thomas Rades.

Crystalline active pharmaceutical ingredients (APIs) often suffer from poor solubility. A common strategy to circumvent this problem is converting APIs into their amorphous form. This has been demonstrated for various APIs, including hydrochlorothiazide. However, the physical properties of polyamorphs are dependent on how they were prepared. Given there are no straightforward techniques to study how molecules interact and organise themselves in amorphous materials, the area is poorly understood.

Nevertheless, a team surrounding Rades and Martins set out to identify how amorphous forms of the same API, presenting different physicochemical properties, differ from each other. They decided to study hydrochlorothiazide as it was previously shown to have polyamorphs with glass transition temperatures above room temperature, which facilitates the preparation, isolation and analysis of its different polyamorphs. Starting from crystalline hydrochlorothiazide, they produced three polyamorphs: polyamorph I via spray-drying, polyamorph II via quench-cooling and polyamorph III by ball-milling. Thermal analysis revealed a significantly lower glass-transition temperature for polyamorph I (88.7°C), whereas polyamorphs II and III had similar glass-transition temperatures (117.5°C and 119.7°C, respectively). The polyamorphs also demonstrated very different shelf-life stabilities against crystallisation.

Subsequently, they studied polyamorphic interconversions by submitting the polyamorphs to the preparation conditions used for other polyamorphs. For example, polyamorph I (obtained by spray-drying) was subjected to quench–cooling or ball-milling. Identifying temperature as a critical parameter, they observed that polyamorph II could be obtained from polyamorphs I and III, but the reverse pathway was not possible. Meanwhile, they observed polyamorph I and polyamorph III interconvert. These results demonstrate polyamorph II is the most stable amorphous form.

Source: © Thomas Rades/University of Copenhagen
Researchers used a variety of techniques to elucidate the different polyamorphs that can be produced from crystalline hydrochlorothiazide and the polyamorphic interconversions that occur when a specific amorphous form is submitted to temperature or milling treatments

‘The problem out of the gate with polyamorphism as a concept is how to tell the difference between a well-defined metastable amorphous structure and an unrelaxed one that simply results from kinetically trapped defects introduced during processing. This is hard to define since the amorphous structure is statistical in any case,’ comments Simon Billinge, who studies the structure of disordered materials at Columbia University in the US. ‘They process the samples very differently. We know—from our own work—that this results in amorphous phases with very different stabilities against recrystallisation, for example, but is this polyamorphism? On the other hand, they find that the pair distribution functions of each of their “forms” are identical. There is no experimental evidence for a distinct structure. Taken together, the results do little to advance my understanding of polyamorphism.’

Distinct dihedral angle distributions

To get further information on how the polyamorphs are different on a molecular level, Martins and Rades turned to molecular dynamics simulations, comparing the dihedral angles around the sulfonamide groups in polyamorphs I and II. ‘Polyamorph I, which has a large number of the molecules with a dihedral angle similar to the one reported for crystalline hydrochlorothiazide, has a lower physical stability and faster structural relaxation time than polyamorph II, which has a broader dihedral angle distribution. Our findings indicate that a broader dihedral angle distribution seems to contribute to a better physical stability and slower structural relaxation,’ says Martins. They therefore hypothesise that having half the molecules with a conformation closer to crystalline hydrochlorothiazide and half of the molecules with a different conformation could help in establishing specific molecular arrangements that would favour the stability of the amorphous form.

The team also says the simulations corroborated its experimental results that polyamorph I can transform into polyamorph II, while the opposite conversion did not take place.

However, Billinge does not believe the computational studies provide conclusive evidence: ‘There is a detailed molecular dynamics analysis where different annealing conditions in the simulations give some slightly different statistics on the molecular conformations, but despite their claim, the resulting computed pair distribution functions do not look like the measured ones, so we have no way of knowing if the molecular dynamics is capturing what is happening in the real material. For amorphous materials, it is very difficult to equilibrate them in a molecular dynamics simulation, so you will be looking at artefacts of how the ensemble was created. Any claims to have found polyamorphism from molecular dynamics simulations by themselves are therefore questionable.’

Rades says their results can change the field of pharmaceutics: ‘We expect that other drug molecules may exhibit polyamorphism and the question would be which structural parameters would be different. In the case of hydrochlorothiazide, the dihedral angle distribution was found to be a parameter contributing for the formation of different polyamorphs. In other drugs, maybe the dihedral angle distribution (molecular conformations) could be different as well, but also maybe the type of intermolecular interactions can play a more important role in the formation of polyamorphs.’

The team now hope the pharmaceutical industry will look at amorphous systems differently and not assume that all amorphous forms of the same compound are the same. ‘Knowing this and considering that a certain polyamorph will have better physical stability, solubility or dissolution properties than another polyamorph, this will be an opportunity for the pharmaceutical industry to prepare tablets of a drug where the dose could be lower than tablets containing the crystalline form,’ concludes Rades.

3rd Harvard Korean Security Summit: “Korea—A Catalyst for Global Trends” [Zoom]

[from Harvard Kennedy School’s Belfer Center, part of Harvard University]

Tuesday, July 19 – Thursday, July 21

RSVP REQUIRED FOR EACH DAY

During July 19-21, 2022, the Korea Project will convene the 3rd Harvard Korean Security Summit. Our theme of “Korea—A Catalyst of Global Trends” explores how quickly various Korea-related functional issues play out with global implications. Korea cases provide unique insights into global trends ranging from ongoing efforts to change leader-level calculus (2017 Korean Missile Crisis) to the ROK’s designs for bolstering tech supply chain resilience to the DPRK’s expanding use of cryptocurrency theft for funding the regime.

Day 1: Tue., July 19, 2022 | 5:00 – 7:30 PM ET  (RSVP for Day 1)
Day 2: Wed., July 20, 2022 | 5:00 – 7:15 PM ET  (RSVP for Day 2)
Day 3: Thu., July 21, 2022 | 5:00 – 7:15 PM ET  (RSVP for Day 3)

Day 1 Agenda (Tuesday, July 19)

5:00 – 5:05 PM ET: Day 1 Overview

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

5:05 – 5:10 PM ET: Korea Foundation’s Opening Remarks

Dr. Geun Lee (President, Korea Foundation)

5:10 – 5:15 PM ET: Belfer Center’s Opening Remarks

Natalie Colbert (Executive Director, Belfer Center, Harvard Kennedy School)

5:15 – 5:20 PM ET: Congratulatory Remarks

The Honorable Dr. Park Jin (Minister of Foreign Affairs, Republic of Korea)

5:20 – 7:25 PM ET: Panel 1: Enhancing Security on the Korean Peninsula

Panelists

General (Ret.) Vincent Brooks (Senior Fellow, Belfer Center, Harvard Kennedy School & Former Commander, ROK-U.S. Combined Forces Command)

Emma Chanlett-Avery (Specialist in Asian Affairs, Congressional Research Service)

General (Ret.) Leem Ho-Young (President, Korea Association of Military Studies & Former Deputy Commander, ROK-U.S. Combined Forces Command)

Dr. Sue Mi Terry (Director, Hyundai Motor-Korea Foundation Center for Korean History and Public Policy, Wilson Center)

The Honorable Dr. Yoon Young-kwan (Former Minister of Foreign Affairs, Republic of Korea)

Moderator

Nick Schifrin (Foreign Affairs and Defense Correspondent, PBS NewsHour) – TBC

7:25 – 7:30 PM ET: Day 1 Wrap-Up

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

Day 2 Agenda (Wednesday, July 20)

5:00 – 5:05 PM ET: Day 2 Overview

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

5:05 – 5:15 PM ET: Day 2 Keynote Remarks

Tami Overby (Senior Director, McLarty Associates & Former President, U.S.-Korea Business Council)

5:15 – 7:10 PM ET: Panel 2: Building Mutual Prosperity Through Resilient Technology Supply Chains

Panelists

The Honorable Dr. Taeho Bark (Former ROK Minister for Trade & President, Lee & Ko Global Commerce Institute)

Ambassador Mark Lippert (Executive Vice President, Head of U.S. Public Affairs, and Chief Risk Officer, Samsung Electronics & Former U.S. Ambassador to the Republic of Korea)

Damien Ma (Managing Director, MacroPolo, Paulson Institute)

Naomi Wilson (Vice President of Policy, Asia, Information Technology Industry Council)

Moderator

Dr. Francesca Giovannini (Executive Director, Managing the Atom Project, Belfer Center, Harvard Kennedy School)

7:10 – 7:15 PM ET: Day 2 Wrap-Up

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

Day 3 Agenda (Thursday, July 21)

5:00 – 5:05 PM ET: Day 3 Overview

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

5:05 – 5:15 PM ET: Day 3 Keynote Remarks

Jean Lee (Host of BBC Podcast Series, The Lazarus Heist)

5:15 – 7:05 PM ET: Panel 3: Addressing North Korea’s Cybercriminal Statecraft Activities

Panelists

Jason Bartlett (Research Associate, Energy, Economics, and Security Program, Center for a New American Security)

Ashley Chafin-Lomonosov (DPRK Cybercrimes Expert, Chainalysis)

Saher Naumaan (Principal Threat Intelligence Analyst, BAE Systems Applied Intelligence)

David Park (Senior Policy Advisor, U.S. Department of the Treasury)

Moderator

Alex O’Neill (Coordinator, Korea Project, Belfer Center, Harvard Kennedy School)

7:05 – 7:10 PM ET: Day 3 Wrap-Up

Dr. John Park (Director, Korea Project, Belfer Center, Harvard Kennedy School)

7:10 – 7:15 PM ET: Closing Remarks

Consul General Kijun You (Korean Consulate General in Boston)

Speaker Biographies

Dr. Taeho Bark is the first president of the Lee & Ko Global Commerce Institute (GCI), newly established in September 2017. Together with the GCI team members working under his supervision, Dr. Bark monitors new developments and trends in global trade and investment, analyzes major international trade dispute cases and provides in-depth advice and strategic insights to Korean and foreign enterprises in connection with their trade and investment-related planning and concerns. Dr. Bark is an internationally renowned trade expert and, among other accomplishments, is a Seoul National University (SNU) Professor Emeritus, who has lectured extensively on international commerce and related subjects, and former Dean of the SNU Graduate School of International Studies (GSIS). In addition to his academic career, Dr. Bark has extensive experience serving as a public official working on trade policy and negotiation matters, having served with distinction as Minister for Trade of the Korean government (December 2011 – March 2013), as well as serving as the Ambassador-at-Large for International Trade and as the Chairman of the International Trade Commission of Korea.

Jason Bartlett is a Research Associate for the Energy, Economics, and Security Program at the Center for a New American Security (CNAS). He analyzes developments and trends in sanctions policy and evasion tactics, proliferation finance, and cyber-enabled financial crime with a regional focus on North Korea, Iran, and Venezuela. He also researches the U.S.–ROK alliance and international security issues, such as North Korean military provocations and cybercrime. Lastly, Bartlett leads research and writing for the CNAS Sanctions by the Numbers series. Prior to joining CNAS, Bartlett worked at various nonprofit research organizations such as C4ADS, the Center for Strategic and International Studies, the Committee for Human Rights in North Korea, and the Asan Institute for Policy Studies in South Korea. He also spent several years volunteering at human rights-focused NGOs resettling North Korean defectors in the United States and South Korea. Bartlett was a 2018-2019 Boren Fellow and Critical Language Scholarship (CLS) recipient in South Korea for Korean language immersion through the U.S. Departments of Defense and State, respectively. He holds a master’s degree in Asian studies and a graduate certificate in refugee and humanitarian emergencies from the School of Foreign Service at Georgetown University. He received a B.S. in Spanish language and literature and a B.A. in international studies from SUNY Oneonta. He also graduated from the Korean Language Institute at Yonsei University in Seoul. Bartlett is fluent in Korean and Spanish. Outside of CNAS, Bartlett is a contributing author for The Diplomat, where he writes on the intersections of cyber, culture, and security in Asia. He is also a member of the North Korea Cyber Working Group at the Harvard Kennedy School’s Belfer Center. His commentary and analysis have appeared in The Wall Street Journal, Government Matters, Business Insider, Yahoo! Finance, The Wire China, NK News, Inkstick Media, Radio Free Asia, Voice of America – Korean, The National Interest, and El País.

General (Ret.) Vincent K. Brooks is a career Army officer who retired from active duty in January 2019 as the four-star general in command of over 650,000 Koreans and Americans under arms. General Brooks is a 1980 graduate of the U.S. Military Academy at West Point, which was the first class to include women. He led the 4,000 cadets as the cadet brigade commander or “First Captain.” A history-maker, Brooks is the first African American to have been chosen for this paramount position, and he was the first cadet to lead the student body when women were in all four classes. He is also the eighth African American in history to attain the military’s top rank – four-star general in the U.S. Army. He holds a Bachelor of Science in Engineering from the U.S. Military Academy at West Point; a Master of Military Art and Science from the prestigious U.S. Army School of Advanced Military Studies at Fort Leavenworth, Kansas; was a National Security Fellow at Harvard University’s John F. Kennedy School of Government. General Brooks also holds an honorary Doctor of Laws from the New England School of Law as well as an honorary Doctor of Humanities from New England Law | Boston. He is a combat veteran and a member of the Council on Foreign Relations. In retirement, General Brooks is a Director of the Gary Sinise Foundation; a non-resident Senior Fellow at Harvard Kennedy School’s Belfer Center for Science and International Affairs; a Distinguished Fellow at the University of Texas, with both the Clements Center for National Security and also the Strauss Center for International Security and Law; an Executive Fellow with the Institute for Defense and Business; and the President of VKB Solutions LLC.

Ashley Chafin-Lomonosov is a Cybercrimes Investigator with Chainalysis, the blockchain data company that serves the public and private sectors globally in order to enable investigations and compliance in the crypto space. Prior to joining Chainalysis, Ashley served in the U.S. government. She leverages the past 10 years of developing financial threat intelligence analysis skills to investigate nation state activity on the blockchain. She specifically focuses on East Asian issues, spending the majority of her time studying DPRK’s tactics, techniques, and procedures on the blockchain. Ashley holds a Master’s in Business Administration and a Bachelor of Arts in Journalism & Public Relations.

Emma Chanlett-Avery is a Specialist in Asian Affairs at the Congressional Research Service. She focuses on U.S. relations with Japan, the Korean Peninsula, Thailand, and Singapore. Ms. Chanlett-Avery joined CRS in 2003 through the Presidential Management Fellowship, with rotations in the State Department on the Korea Desk and at the Joint U.S. Military Advisory Group in Bangkok, Thailand. She also worked in the Office of Policy Planning as a Harold Rosenthal Fellow. She is a member of the Mansfield Foundation U.S.-Japan Network for the Future, Vice-Chair of the Board of Trustees of the Japan America Society of Washington, and the 2016 recipient of the Kato Prize. Ms. Chanlett-Avery received an M.A. in international security policy from the School of International and Public Affairs at Columbia University and her B.A. in Russian studies from Amherst College.

Natalie Colbert is the Belfer Center’s Executive Director. Before coming to the Belfer Center, Colbert served in the Central Intelligence Agency for 13 years. Most recently, she was Director of Analytic Resources and Corporate Programs for the Near East Mission Center, where she led strategic management of analytic personnel resources and created a career development seminar for mid-level analysts. Prior to this role, Colbert led multiple analytic teams to produce intelligence assessments covering fast-paced issues in the Middle East for the President and other customers in the policymaking, intelligence, and military communities. Colbert previously served as an intelligence analyst covering conflict zones in Africa and Latin America. Across her CIA career, Colbert has earned awards for leadership excellence and in 2021 received the Near East Mission Center Award for Excellence in Diversity, Equity, and Inclusion. Colbert is a 2008 graduate of Harvard Kennedy School, where she earned a Master in Public Policy. She graduated in 2006 from New York University, majoring in International Relations and Francophone Studies.

Dr. Francesca Giovannini is the Executive Director of the Project on Managing the Atom at the Harvard Kennedy School’s Belfer Center for Science and International Affairs. In addition, she is a non-residential fellow at the Centre for International Security and Cooperation at Stanford University. Dr. Giovannini served as Strategy and Policy Officer to the Executive Secretary of the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO), based in Vienna. In that capacity, she oversaw a series of policy initiatives to promote CTBT ratification as a confidence-building mechanism in regional and bilateral nuclear negotiations, elevate the profile of CTBT in academic circles and promote the recruitment of female scientists from the Global South. Prior to her international appointment, Dr. Giovannini served for five years at the American Academy of Arts and Sciences in Boston as Director of the Research Program on Global Security and International Affairs. Working to leverage academic knowledge to inform better policies, she led and promoted countless academic research on issues such as bilateral and multilateral arms control frameworks, regional nuclear proliferation dynamics, and nuclear security and insider threats. With a Doctorate from the University of Oxford and two Masters from the University of California, Berkeley, Dr. Giovannini began her career working for international organizations and the Italian Ministry of Foreign Affairs.

Dr. Geun Lee was appointed President of the Korea Foundation in September 2019. Prior to joining the Korea Foundation, he was a professor of International Relations at the Graduate School of International Studies, Seoul National University, and former Dean of Office of International Affairs, Seoul National University. From 2015 to 2016, he was visiting Super Global Professor at Keio University in Japan. He is also former Chair of the Global Agenda Council on the Future of Korea at the World Economic Forum (Davos Forum), and currently a member of the Global Future Council of the World Economic Forum. Before joining the faculty of Seoul National University, he served as a professor at the ROK Ministry of Foreign Affairs’ Institute of Foreign Affairs and National Security (which is now part of the Korea National Diplomatic Academy). He also served as President of an independent think tank, Korea Institute for Future Strategies from 2003-2007. His publications include “Clash of Soft Power between China and Japan,” “A Theory of Soft Power and Korea’s Soft Power Strategy,” “The Nexus between Korea’s Regional Security Options and Domestic Politics,” “U.S. Global Defense Posture Review and its Implications on the U.S.-Korea Relations.” He co-authored The Environmental Dimension of Asian Security. Dr. Lee received his B.A. in political science from Seoul National University, and M.A. and Ph.D. in political science from the University of Wisconsin at Madison.

Jean Lee is a veteran foreign correspondent and expert on North Korea. Lee led the Associated Press (AP) news agency’s coverage of the Korean Peninsula as bureau chief from 2008 to 2013. In 2011, she became the first American reporter granted extensive access on the ground in North Korea, and in January 2012 opened AP’s Pyongyang bureau, the only U.S. text/photo news bureau based in the North Korean capital. She has made dozens of extended reporting trips to North Korea, visiting farms, factories, schools, military academies, and homes in the course of her exclusive reporting across the country. During Lee’s tenure, AP’s coverage of Kim Jong Il’s 2011 death earned an honorable mention in the deadline reporting category of the 2012 Associated Press Media Editors awards for journalism in the United States and Canada. Lee also won an Online Journalism Award in 2013 for her role in using photography, video, and social media in North Korea. Lee is a native of Minneapolis. She has a bachelor’s degree in East Asian Studies and English from Columbia University, and a master’s degree from the Columbia Graduate School of Journalism. She worked as a reporter for the Korea Herald in Seoul, South Korea, before being posted with AP to the news agency’s bureaus in Baltimore, Fresno, San Francisco, New York, London, Seoul, and Pyongyang. Lee served as a Wilson Center Public Policy Scholar and Global Fellow before joining the Asia Program as Korea Center program director. She has contributed commentary and feature stories to the New York Times Sunday Review, Esquire magazine, the New Republic and other publications. She appears as an analyst for CNN, BBC, NPR, PRI, and other media, and serves frequently as a guest speaker on Korea-related topics. She is a member of the National Committee on North Korea, the Council of Korean Americans, the Asian American Journalists Association, and the Pacific Council. She serves on the World Economic Forum’s Global Futures Council on the Korean Peninsula. She is co-host of the Lazarus Heist podcast on the BBC World Service.

General (Ret.) Leem Ho-Young is the President of the Korea Association of Military Studies, a nonprofit think tank operating under the auspices of the ROK Ministry of National Defense. He is also the Vice Chairman of the Korea Defense Veterans Association and Vice President of the Korea-U.S. Alliance Foundation. Previously, General Leem was the Commander of the Ground Component Command and Deputy Commander of the ROK-U.S. Combined Forces Command from 2016 to 2017. General Leem has served as the ROK Army’s Director of Audit and Inspection and the Director of Strategy and Planning for the ROK Joint Chiefs of Staff. He has been a lifelong Infantry officer since his graduation from the Korea Military Academy, Class Number 38.

Ambassador Mark Lippert has had a distinguished career in the U.S. government that spanned approximately two decades and included a series of senior-level positions across multiple agencies. From 2014-2017, he served as the U.S. ambassador extraordinary and plenipotentiary to the Republic of Korea, based in Seoul. He previously held positions in the Department of Defense, including as chief of staff to Secretary of Defense Chuck Hagel (2013-2014) and as assistant secretary of defense for Asian and Pacific Security Affairs (2012-2013), the top official in the Pentagon for all Asia issues. Lippert also worked in the White House as chief of staff to the National Security Council in 2009. Lippert served in the uniformed military. An intelligence officer in the U.S. Navy, he mobilized to active duty from 2009 to 2011 for service with Naval Special Warfare (SEALs) Development Group that included deployments to Afghanistan and other regions. From 2007 to 2008, he deployed as an intelligence officer with Seal Team One to Anbar Province, Iraq in support of Operation Iraqi Freedom. Earlier in his career, Lippert served as a staff member in the U.S. Senate, where he worked on the Senate Foreign Relations Committee for then-Senator Obama; the Senate Appropriations Committee State-Foreign Operations Subcommittee for Senator Leahy, and for other members of the Senate. His awards and decorations include the Bronze Star Medal for his service in Iraq, the Defense Meritorious Service Medal, and the Basic Parachutist Badge. He is also the recipient of the Department of Defense’s Distinguished Public Service Award and the Department of the Navy’s Distinguished Public Service Award. He graduated Phi Beta Kappa from Stanford University with a B.A. in political science and holds an M.A. in international policy studies from the same institution. He speaks Korean and also studied Mandarin Chinese at Beijing University.

Damien Ma is Managing Director and co-founder of MacroPolo, the Think Tank of the Paulson Institute. He is the author or editor of the books, In Line Behind a Billion People: How Scarcity Will Define China’s Ascent in the Next Decade, The Economics of Air Pollution in China (by Ma Jun), and China’s Economic Arrival: Decoding a Disruptive Rise, published by Palgrave Macmillan. He is also adjunct faculty at the Kellogg School of Management at Northwestern University. Previously, Ma was a Senior Analyst at Eurasia Group, the political risk research and advisory firm. At Eurasia Group, he mainly focused on the China and East Asian markets, covering areas that spanned energy and commodities and industrial policy to elite politics and U.S.-China relations. He also led work on analyzing Mongolian politics and its mining sector. His advisory and analytical work served a range of clients from institutional investors and multinationals to the U.S., Japanese, and Singaporean governments. Prior to joining Eurasia Group, he was a manager of publications at the U.S.-China Business Council in Washington, D.C., where he was also an adjunct instructor at Johns Hopkins SAIS. Early in his career, he worked at public relations firm H-Line Ogilvy in Beijing, where he served multinational clients. In addition, Ma has published widely, including in The Atlantic, New York Times, Foreign Affairs, The New Republic, Foreign Policy, and Bloomberg, among others. He has also appeared in a range of broadcast media such as the Charlie Rose Show, BBC, NPR, and CNBC. In addition to media appearances, Ma has keynoted or spoken at various industry, investor, and academic conferences, including CLSA and Credit Suisse Latin America. Ma was named a “99under33” foreign policy leader by the Young Professionals in Foreign Policy. He speaks fluent Mandarin Chinese.

Saher Naumaan is Principal Threat Intelligence Analyst at BAE Systems Applied Intelligence. She currently researches state-sponsored cyber espionage with a focus on threat groups and activity in the Middle East. Saher specialises in analysis covering the intersection of geopolitics and cyber operations, and regularly speaks at public and private conferences around the world, including SAS, Virus Bulletin, FIRST, and Bsides. Prior to working at Applied Intelligence, Saher graduated from King’s College London with a Master’s in Intelligence and Security, where she received the Barrie Paskins Award for Best MA dissertation in War Studies.

Alex O’Neill is Coordinator of the Korea Project and an Associate at the Belfer Center for Science and International Affairs. He is also a Co-Founder of the Belfer Center’s North Korea Cyber Working Group. As Coordinator, Alex helps oversee all Korea Project events and initiatives, including the annual Harvard Korean Security Summit. He previously worked as Research Assistant to Prof. Matthew Bunn at the Belfer Center’s Project on Managing the Atom. Alex’s work focuses on North Korean financially motivated cyber operations, as well as links between North Korean and Russian-speaking criminals. His most recent research publication is “Cybercriminal Statecraft: North Korean Hackers’ Ties to the Global Underground.” Alex is a member of the Advisory Board of the International Refugee Assistance Project and of the Young Professionals Briefing Series at the Council on Foreign Relations. He speaks fluent Spanish and has advanced proficiency in Russian. Alex holds an M.Sc. in Russian and East European Studies from the University of Oxford and a B.A. in History from Yale University.

Tami Overby is Board Director for The Korea Society and Senior Director at McLarty Associates, where she advises clients on Asia and trade matters, with a particular focus on Korea. She has three decades of Asia work, including 21 years living and working in Seoul. Her most recent experience includes eight years leading the U.S. Chamber of Commerce’s Asia team while also serving as President of the U.S.-Korea Business Council. Ms. Overby’s extensive experience helps American companies compete and prosper in Asia. She attended many of the TransPacific Partnership (TPP) negotiating rounds, often leading the American business delegation to help ensure U.S. firms’ priorities were well understood by the negotiating partners. She oversaw the U.S. Coalition for TPP, an alliance led by the U.S. Chamber, the Business Roundtable, the National Association of Manufacturers, the Farm Bureau, and the Emergency Committee for Trade.

David Park is a Senior Policy Advisor in the U.S. Treasury Department’s Office of Terrorist Financing and Financial Crimes (TFFC). He advises senior leadership on policies and strategies that utilize Treasury’s tools to compete against China in the national security context, including in the technology, economy, and military spheres. He is also responsible for developing polices and strategies that seek to counter Chinese illicit financing, money laundering, financial crimes, corruption, and human rights abuses to advance U.S. national interests in the Indo-Pacific. Previously, David was the first U.S. Treasury Representative to Korea. While there, he advised U.S. government (USG) senior officials and agencies on North Korea sanctions, economy, and illicit financing and sought ways to work cooperatively with ROK institutions to enhance the USG’s pressure campaign on North Korea. Before his assignment to Korea, David was Senior Advisor to the Acting Assistant Secretary and Deputy Assistant Secretary (DAS) for TFFC, advising her on countering terrorist financing, proliferation financing, money laundering, corruption, and financial crimes issues. David began his Treasury career as a Policy Advisor, responsible for developing Treasury’s strategy and policy to counter North Korean illicit financing, financial crimes, and sanctions evasion. Before Treasury, David served in the Office of U.S. Senator Joe Donnelly as a Defense and Foreign Affairs Legislative Staffer. In this role, he advised the Senator on his Senate Armed Services Committee work and advanced U.S. national interests through the annual National Defense Authorization Act. David began his public service career as an officer in the U.S. Air Force. In the Air Force, he served with service members from all the service branches, the ROK Air Force in Korea, and NATO nations in Belgium. David earned his B.A. with honors from the University of California, Berkeley, MPA from the University of Oklahoma, and MA from The Fletcher School of Law and Diplomacy, Tufts University.

Dr. Park Jin is Minister of Foreign Affairs of the Republic of Korea. He previously served four terms as a Member of the National Assembly (16th, 17th, 18th, 21st), including as a member of the Science, Technology, Information and Communication Committee (2002-2004), a ranking member of the National Defense Committee (2004-2006), a member of the Intelligence Oversight Committee (2004-2006), a member of the Foreign Affairs, Trade and Unification Committee (2006-2010) and a ranking member of the Knowledge Economy Committee (2010-2012). He served as the Chairman of the Foreign Affairs, Trade and National Unification Committee from 2008-2010. In that capacity, he passed the KORUS FTA, Korea-EU FTA, North Korea Human Rights Act, ODA Law and PKO Law. He was also actively involved in parliamentary diplomacy with the U.S., the U.K., China, Japan, ASEAN, Central Asia, Israel and the Middle East. He previously served as the Presidential Secretary for Press Affairs and later Political Affairs under the Kim Young-sam administration (1993-1998) before being elected parliamentary member in August 2002 in Seoul. During his private life, Dr. Park led the Asia Future Institute (AFI), an independent policy think-tank established in 2013 and designed to conduct research on economic, political and strategic issues in Asia and promote Korea’s role in the Asia-Pacific region. He also served as the Chairman of Korea-America Association (KAA), which was created in 1963 to promote mutual understanding, friendship and cooperation between Korea and the United States. He served as a Global Fellow of the Woodrow Wilson International Center for Scholars in Washington D.C. from 2014 to 2021. Dr. Park also taught as an endowed Chair Professor at the Graduate School of International and Area Studies of Hankuk University of Foreign Studies. Previously he led the Korea-Britain Society as the Executive President (2007-2017). With great affection for the sea, he served in the Korean military as a Navy officer, Lieutenant JG (1980-1983) lecturing naval cadets in the Korean Naval Academy in Jinhae. Dr. Park graduated from the College of Law at Seoul National University (B.A.), Kennedy School of Government at Harvard University (MPA), New York University Law School (LL.M.) and received a doctorate degree (D. Phil.) in politics from St. Antony’s College, Oxford University.

Dr. John Park is Director of the Korea Project at the Harvard Kennedy School’s Belfer Center for Science and International Affairs. He is also a Faculty Member of the Committee on Regional Studies East Asia, an Associated Faculty Member of the Korea Institute, and a Faculty Affiliate with the Project on Managing the Atom. His core research projects focus on the political economy of the Korean Peninsula, nuclear proliferation, economic statecraft, Asian trade negotiations, and North Korean cyber operations. He previously worked at Goldman Sachs and The Boston Consulting Group. Dr. Park presented a TEDxPaloAlto talk in 2019 titled “How North Korea Inc. Evades Sanctions Through Innovation.” Dr. Park’s key publications include: “Stopping North Korea, Inc.: Sanctions Effectiveness and Unintended Consequences,” (MIT Security Studies Program, 2016 – co-authored with Jim Walsh); “The Key to the North Korean Targeted Sanctions Puzzle,” The Washington Quarterly (Fall 2014); “Assessing the Role of Security Assurances in Dealing with North Korea” in Security Assurances and Nuclear Nonproliferation (Stanford University Press, 2012); “North Korea, Inc.: Gaining Insights into North Korean Regime Stability from Recent Commercial Activities” (USIP Working Paper, May 2009); and “North Korea’s Nuclear Policy Behavior: Deterrence and Leverage,” in The Long Shadow: Nuclear Weapons and Security in 21st Century Asia (Stanford University Press, 2008). Dr. Park received his Ph.D. from the University of Cambridge, where he was a Social Sciences and Humanities Research Council Doctoral Fellow. He completed his pre-doctoral and post-doctoral training at the Harvard Kennedy School’s Belfer Center.

Nick Schifrin is the foreign affairs and defense correspondent for PBS NewsHour, based in Washington, D.C. He leads NewsHour’s foreign reporting and has created week-long, in-depth series for NewsHour from China, Russia, Ukraine, Nigeria, Egypt, Kenya, Cuba, Mexico, and the Baltics. The PBS NewsHour series “Inside Putin’s Russia” won a 2018 Peabody Award and the National Press Club’s Edwin M. Hood Award for Diplomatic Correspondence. In November 2020, Schifrin received the American Academy of Diplomacy’s Arthur Ross Media Award for Distinguished Reporting and Analysis of Foreign Affairs. Prior to PBS NewsHour, Schifrin was Al Jazeera America’s Middle East correspondent. He won an Overseas Press Club Award for his Gaza coverage and a National Headliners Award for his Ukraine coverage. From 2008-2012, Schifrin served as the ABC News correspondent in Afghanistan and Pakistan. In 2011, he was one of the first journalists to arrive in Abbottabad, Pakistan, after Osama bin Laden’s death and delivered one of the year’s biggest exclusives: the first video from inside bin Laden’s compound. His reporting helped ABC News win an Edward R. Murrow Award for its bin Laden coverage. He has a Master of International Public Policy degree from the Johns Hopkins School of Advanced International Studies (SAIS), with a concentration in Strategic Studies.

Dr. Sue Mi Terry is Director of the Asia Program and the Hyundai Motor-Korea Foundation Center for Korean History and Public Policy at the Wilson Center. Prior to joining the Wilson Center, Dr. Terry served in a range of important policy roles related to both Korea and its surrounding region. Formerly a Senior Fellow with the Korea Chair at the Center for Strategic and International Studies (CSIS), she served as a Senior Analyst on Korean issues at the CIA (2001-2008), where she produced hundreds of intelligence assessments – including a record number of contributions to the President’s Daily Brief, the Intelligence Community’s most prestigious product. She received numerous awards for her leadership and outstanding mission support, including the CIA Foreign Language award in 2008. From 2008 to 2009, Dr. Terry was the Director for Korea, Japan, and Oceanic Affairs at the National Security Council under both President George W. Bush and President Barack Obama. In that role, she formulated, coordinated, and implemented U.S. government policy on Korea and Japan, as well as Australia, New Zealand, and Oceania. From 2009 to 2010, she was Deputy National Intelligence Officer for East Asia at the National Intelligence Council. In that position, she led the U.S. Intelligence community’s production of strategic analysis on East Asian issues and authored multiple National Intelligence Estimates. From 2010 to 2011, Dr. Terry served as the National Intelligence Fellow in the David Rockefeller Studies Program at the Council on Foreign Relations in New York. Since leaving the government, Dr. Terry has been a Senior Research Scholar at Columbia University’s Weatherhead East Asian Institute (2011-2015), where she taught both graduate and undergraduate courses on Korean politics and East Asia. She holds a Ph.D. (2001) and an M.A. (1998) in international relations from the Fletcher School of Law and Diplomacy at Tufts University and a B.A. in political science from New York University (1993).

Naomi Wilson serves as vice president of policy, Asia at the Information Technology Industry Council. Prior to joining ITI, Naomi served at the U.S. Department of Homeland Security (DHS), where she most recently held the position of acting director for Asia-Pacific. In that capacity, she played a leading role on cybersecurity, law enforcement, and customs cooperation issues related to Asia and served as a senior advisor to Secretary Jeh Johnson. During her tenure at DHS, Naomi led development and implementation of priority policy initiatives for DHS engagement with China, including secretarial engagements and agreements. She worked closely with interagency colleagues to negotiate and implement agreements stemming from the September 2015 State visit between Presidents Barack Obama and Xi Jinping, including managing the U.S.–China High-Level Dialogue on Cybercrime and Related Issues for DHS. Prior to joining DHS, Naomi served as a staffer on the Senate Committee on Homeland Security & Governmental Affairs and as a research assistant at the Center for Strategic & International Studies (CSIS). Naomi holds a Bachelor’s degree in English and Master’s in International Affairs & National Security. In 2011, she completed intensive Chinese language training at Peking University. Naomi speaks advanced Mandarin and French and is a native of Connecticut.

Dr. Yoon Young-kwan served as the inaugural Senior Visiting Scholar with the Korea Project at the Harvard Kennedy School’s Belfer Center for Science and International Affairs. He also served as the 2021 Kim Koo Visiting Professor at the Korea Institute at Harvard University. He is Professor Emeritus in the Department of Political Science and International Relations, Seoul National University. He served as Minister of Foreign Affairs and Trade of the Republic of Korea from 2003 to 2004. Before he joined the faculty of Seoul National University in 1990, he taught at the University of California at Davis. He served as Korea’s Eminent Representative to, and co-chair of, the East Asia Vision Group II from September 2011 to October 2012. He has published several books and some 70 articles in the fields of international political economy, Korea’s foreign policy, and inter-Korean relations, some of which appeared in World Politics, International Political Science Review, Asian Survey, and Project Syndicate. Dr. Yoon received his doctoral degree from the School of Advanced International Studies at Johns Hopkins University.

Consul General Kijun You serves in the Korean Consulate General in Boston. His previous positions in the ROK Ministry of Foreign Affairs include: Director-General for International Legal Affairs; Deputy Director-General for International Legal Affairs; Minister-Counsellor, Korean Embassy in the Republic of Kenya; Counsellor, Korean Permanent Mission to the United Nations in New York; Director, Territory and Oceans Division, Treaties Bureau. Consul General You received his B.A. in French Language and Literature at Korea University, Master of Law from Korea University, LL.M. from the University of Edinburgh, and LL.M. from the London School of Economics and Political Science.

“The Parliament of Man, the Federation of the World”

A Visionary Line from Tennyson’s Poem

“Locksley Hall” by Alfred, Lord Tennyson

Among the most optimistic visions ever put in poems or speeches are these words from the poet Tennyson. The line from his poem, “Locksley Hall,” envisions “The Parliament of man, the Federation of the world” which remains a vision of human solidarity that haunts the imagination.

The larger couplet in the poem captures the idea of a post-violent and post-anarchic world:

“Till the war-drum throbb’d no longer, and the battle-flags were furl’d
In the Parliament of man, the Federation of the world.”

“Locksley Hall” (1835/1842)

Comrades, leave me here a little, while as yet’t is early morn:
Leave me here, and when you want me, sound upon the bugle-horn.

’T is the place, and all around it, as of old, the curlews call,
Dreary gleams about the moorland flying over Locksley Hall;

Locksley Hall, that in the distance overlooks the sandy tracts,
And the hollow ocean-ridges roaring into cataracts.

Many a night from yonder ivied casement, ere I went to rest,
Did I look on great Orion sloping slowly to the West.

Many a night I saw the Pleiads, rising thro’ the mellow shade,
Glitter like a swarm of fire-flies tangled in a silver braid.

Here about the beach I wander’d, nourishing a youth sublime
With the fairy tales of science, and the long result of Time;

When the centuries behind me like a fruitful land reposed;
When I clung to all the present for the promise that it closed:

When I dipt into the future far as human eye could see;
Saw the Vision of the world and all the wonder that would be.—

In the Spring a fuller crimson comes upon the robin’s breast;
In the Spring the wanton lapwing gets himself another crest;

In the Spring a livelier iris changes on the burnish’d dove;
In the Spring a young man’s fancy lightly turns to thoughts of love.

Then her cheek was pale and thinner than should be for one so young,
And her eyes on all my motions with a mute observance hung.

And I said, ”My cousin Amy, speak, and speak the truth to me,
Trust me, cousin, all the current of my being sets to thee.”

On her pallid cheek and forehead came a colour and a light,
As I have seen the rosy red flushing in the northern night.

And she turn’d—her bosom shaken with a sudden storm of sighs—
All the spirit deeply dawning in the dark of hazel eyes—

Saying, ”I have hid my feelings, fearing they should do me wrong”;
Saying, ”Dost thou love me, cousin?” weeping, ”I have loved thee long.”

Love took up the glass of Time, and turn’d it in his glowing hands;
Every moment, lightly shaken, ran itself in golden sands.

Love took up the harp of Life, and smote on all the chords with might;
Smote the chord of Self, that, trembling, pass’d in music out of sight.

Many a morning on the moorland did we hear the copses ring,
And her whisper throng’d my pulses with the fulness of the Spring.

Many an evening by the waters did we watch the stately ships,
And our spirits rush’d together at the touching of the lips.

O my cousin, shallow-hearted! O my Amy, mine no more!
O the dreary, dreary moorland! O the barren, barren shore!

Falser than all fancy fathoms, falser than all songs have sung,
Puppet to a father’s threat, and servile to a shrewish tongue!

Is it well to wish thee happy?—having known me—to decline
On a range of lower feelings and a narrower heart than mine!

Yet it shall be; thou shalt lower to his level day by day,
What is fine within thee growing coarse to sympathize with clay.

As the husband is, the wife is: thou art mated with a clown,
And the grossness of his nature will have weight to drag thee down.

He will hold thee, when his passion shall have spent its novel force,
Something better than his dog, a little dearer than his horse.

What is this? his eyes are heavy; think not they are glazed with wine.
Go to him, it is thy duty, kiss him, take his hand in thine.

It may be my lord is weary, that his brain is overwrought:
Soothe him with thy finer fancies, touch him with thy lighter thought.

He will answer to the purpose, easy things to understand—
Better thou wert dead before me, tho’ I slew thee with my hand!

Better thou and I were lying, hidden from the heart’s disgrace,
Roll’d in one another’s arms, and silent in a last embrace.

Cursed be the social wants that sin against the strength of youth!
Cursed be the social lies that warp us from the living truth!

Cursed be the sickly forms that err from honest Nature’s rule!
Cursed be the gold that gilds the straiten’d forehead of the fool!

Well—’t is well that I should bluster!—Hadst thou less unworthy proved—
Would to God—for I had loved thee more than ever wife was loved.

Am I mad, that I should cherish that which bears but bitter fruit?
I will pluck it from my bosom, tho’ my heart be at the root.

Never, tho’ my mortal summers to such length of years should come
As the many-winter’d crow that leads the clanging rookery home.

Where is comfort? in division of the records of the mind?
Can I part her from herself, and love her, as I knew her, kind?

I remember one that perish’d; sweetly did she speak and move;
Such a one do I remember, whom to look at was to love.

Can I think of her as dead, and love her for the love she bore?
No—she never loved me truly; love is love for evermore.

Comfort? comfort scorn’d of devils! this is truth the poet sings,
That a sorrow’s crown of sorrow is remembering happier things.

Drug thy memories, lest thou learn it, lest thy heart be put to proof,
In the dead unhappy night, and when the rain is on the roof.

Like a dog, he hunts in dreams, and thou art staring at the wall,
Where the dying night-lamp flickers, and the shadows rise and fall.

Then a hand shall pass before thee, pointing to his drunken sleep,
To thy widow’d marriage-pillows, to the tears that thou wilt weep.

Thou shalt hear the ”Never, never,” whisper’d by the phantom years,
And a song from out the distance in the ringing of thine ears;

And an eye shall vex thee, looking ancient kindness on thy pain.
Turn thee, turn thee on thy pillow; get thee to thy rest again.

Nay, but Nature brings thee solace; for a tender voice will cry.
’T is a purer life than thine, a lip to drain thy trouble dry.

Baby lips will laugh me down; my latest rival brings thee rest.
Baby fingers, waxen touches, press me from the mother’s breast.

O, the child too clothes the father with a dearness not his due.
Half is thine and half is his: it will be worthy of the two.

O, I see thee old and formal, fitted to thy petty part,
With a little hoard of maxims preaching down a daughter’s heart.

“They were dangerous guides the feelings—she herself was not exempt—
Truly, she herself had suffer’d”—Perish in thy self-contempt!

Overlive it—lower yet—be happy! wherefore should I care?
I myself must mix with action, lest I wither by despair.

What is that which I should turn to, lighting upon days like these?
Every door is barr’d with gold, and opens but to golden keys.

Every gate is throng’d with suitors, all the markets overflow.
I have but an angry fancy; what is that which I should do?

I had been content to perish, falling on the foeman’s ground,
When the ranks are roll’d in vapour, and the winds are laid with sound.

But the jingling of the guinea helps the hurt that Honour feels,
And the nations do but murmur, snarling at each other’s heels.

Can I but relive in sadness? I will turn that earlier page.
Hide me from my deep emotion, O thou wondrous Mother-Age!

Make me feel the wild pulsation that I felt before the strife,
When I heard my days before me, and the tumult of my life;

Yearning for the large excitement that the coming years would yield,
Eager-hearted as a boy when first he leaves his father’s field,

And at night along the dusky highway near and nearer drawn,
Sees in heaven the light of London flaring like a dreary dawn;

And his spirit leaps within him to be gone before him then,
Underneath the light he looks at, in among the throngs of men:

Men, my brothers, men the workers, ever reaping something new:
That which they have done but earnest of the things that they shall do:

For I dipt into the future, far as human eye could see,
Saw the Vision of the world, and all the wonder that would be;

Saw the heavens fill with commerce, argosies of magic sails,
Pilots of the purple twilight dropping down with costly bales;

Heard the heavens fill with shouting, and there rain’d a ghastly dew
From the nations’ airy navies grappling in the central blue;

Far along the world-wide whisper of the south-wind rushing warm,
With the standards of the peoples plunging thro’ the thunder-storm;

Till the war-drum throbb’d no longer, and the battle-flags were furl’d
In the Parliament of man, the Federation of the world.

There the common sense of most shall hold a fretful realm in awe,
And the kindly earth shall slumber, lapt in universal law.

So I triumph’d ere my passion sweeping thro’ me left me dry,
Left me with the palsied heart, and left me with the jaundiced eye;

Eye, to which all order festers, all things here are out of joint:
Science moves, but slowly, slowly, creeping on from point to point:

Slowly comes a hungry people, as a lion, creeping nigher,
Glares at one that nods and winks behind a slowly-dying fire.

Yet I doubt not thro’ the ages one increasing purpose runs,
And the thoughts of men are widen’d with the process of the suns.

What is that to him that reaps not harvest of his youthful joys,
Tho’ the deep heart of existence beat for ever like a boy’s?

Knowledge comes, but wisdom lingers, and I linger on the shore,
And the individual withers, and the world is more and more.

Knowledge comes, but wisdom lingers, and he bears a laden breast,
Full of sad experience, moving toward the stillness of his rest.

Hark, my merry comrades call me, sounding on the bugle-horn,
They to whom my foolish passion were a target for their scorn:

Shall it not be scorn to me to harp on such a moulder’d string?
I am shamed thro’ all my nature to have loved so slight a thing.

Weakness to be wroth with weakness! woman’s pleasure, woman’s pain—
Nature made them blinder motions bounded in a shallower brain:

Woman is the lesser man, and all thy passions, match’d with mine,
Are as moonlight unto sunlight, and as water unto wine—

Here at least, where nature sickens, nothing. Ah, for some retreat
Deep in yonder shining Orient, where my life began to beat;

Where in wild Mahratta-battle fell my father evil-starr’d,—
I was left a trampled orphan, and a selfish uncle’s ward.

Or to burst all links of habit—there to wander far away,
On from island unto island at the gateways of the day.

Larger constellations burning, mellow moons and happy skies,
Breadths of tropic shade and palms in cluster, knots of Paradise.

Never comes the trader, never floats an European flag,
Slides the bird o’er lustrous woodland, swings the trailer from the crag;

Droops the heavy-blossom’d bower, hangs the heavy-fruited tree—
Summer isles of Eden lying in dark-purple spheres of sea.

There methinks would be enjoyment more than in this march of mind,
In the steamship, in the railway, in the thoughts that shake mankind.

There the passions cramp’d no longer shall have scope and breathing space;
I will take some savage woman, she shall rear my dusky race.

Iron-jointed, supple-sinew’d, they shall dive, and they shall run,
Catch the wild goat by the hair, and hurl their lances in the sun;

Whistle back the parrot’s call, and leap the rainbows of the brooks,
Not with blinded eyesight poring over miserable books—

Fool, again the dream, the fancy! but I know my words are wild,
But I count the gray barbarian lower than the Christian child.

I, to herd with narrow foreheads, vacant of our glorious gains,
Like a beast with lower pleasures, like a beast with lower pains!

Mated with a squalid savage—what to me were sun or clime?
I the heir of all the ages, in the foremost files of time—

I that rather held it better men should perish one by one,
Than that earth should stand at gaze like Joshua’s moon in Ajalon!

Not in vain the distance beacons. Forward, forward let us range,
Let the great world spin for ever down the ringing grooves of change.

Thro’ the shadow of the globe we sweep into the younger day;
Better fifty years of Europe than a cycle of Cathay.

Mother-Age (for mine I knew not) help me as when life begun:
Rift the hills, and roll the waters, flash the lightnings, weigh the Sun.

O, I see the crescent promise of my spirit hath not set.
Ancient founts of inspiration well thro’ all my fancy yet.

Howsoever these things be, a long farewell to Locksley Hall!
Now for me the woods may wither, now for me the roof-tree fall.

Comes a vapour from the margin, blackening over heath and holt,
Cramming all the blast before it, in its breast a thunderbolt.

Let it fall on Locksley Hall, with rain or hail, or fire or snow;
For the mighty wind arises, roaring seaward, and I go.

Cultural Influence

The historian Arthur Schlesinger Jr., writing in The Wall Street Journal, quoted the poem to illustrate “a noble dream” that modern US policy decisions may have been neglecting, and he also stated that Winston Churchill considered it “the most wonderful of modern prophecies” and Harry S. Truman carried the words in his wallet.

Lord Tennyson wrote a sequel to “Locksley Hall” in 1886, “Locksley Hall Sixty Years After” [PDF]. In the sequel Tennyson describes how the industrialized nature of Britain has failed to fulfill the expectations of the poem of 1842.

A line in “Locksley Hall” would inspire the title of the historian Paul Kennedy’s 2006 book on the United Nations, The Parliament of Man: The Past, Present, and Future of the United Nations.

…

In a scene from the American film Marathon Man, graduate student Thomas “Babe” Levy (portrayed by actor Dustin Hoffman) attends an exclusive seminar at Columbia University. During the seminar, his irritable professor, played by Fritz Weaver, quotes the line “Let us hush this cry of ‘Forward’ till ten thousand years have gone” from “Locksley Hall Sixty Years After” [PDF] and then asks if anyone recognizes it. Hoffman’s character is the only one who does (he writes down the title in his notes) but does not reveal this to the class. The professor calls him out on this after dismissing the other students.

In the television program Star Trek: Voyager, the dedication plaque of the USS Voyager quotes from the poem: “For I dipt in to the future, far as human eye could see; Saw the vision of the world, and all the wonder that would be.”

…

“Locksley Hall” is also the source of the title of Colum McCann’s 2009 novel, Let the Great World Spin.

Also, it includes one of the most famous lines in all of English poetry, the last of the following four, albeit very few are aware of the poem whence it came, and it is often, perhaps usually, misquoted:

In the spring a fuller crimson comes upon the robin’s breast
In the spring the wanton lapwing gets himself another crest

In the spring a livelier iris changes on the burnished dove
In the spring a young man’s fancy lightly turns to thoughts of love.

James Thurber illustrated this poem for Fables for Our Time and Famous Poems Illustrated.

Elizabeth Gaskell mentions the poem in her 1853 novel Cranford. Lines from it are quoted in the 2007 adaptation of the novel.

(Wikipedia)

Alfred, Lord Tennyson, 1st Baron Tennyson FRS was an English poet. He was the Poet Laureate during much of Queen Victoria’s reign and remains one of the most popular British poets. In 1829, Tennyson was awarded the Chancellor’s Gold Medal at Cambridge for one of his first pieces, “Timbuctoo” [PDF, now more commonly written “Timbuktu”].

Born: August 6, 1809, Somersby, United Kingdom
Died: October 6, 1892, Lurgashall, United Kingdom

Essay 64: Neuroscience by Itself Limited

Senators John McCain of Arizona and Edward Kennedy of Massachusetts died in recent years of brain tumors (such as gliomas and glioblastomas). It is perfectly reasonable to wonder if neuroscience, neuropathology and brain science might one day be able to vaporize tumors without damaging the “host” brain at all.  Who could possibly be against such progress?  After all, if you had an impacted wisdom tooth and could choose between seeing an oral surgeon at a major hospital or going to a dentist at the time of Plato, you would choose the oral surgeon. 

These truths obscure a deeper problem in all “reductivist” sciences namely the relationships between the brain and the mind and the person.  This was anticipated by Gabriel Marcel (died 1973) when he wrote in his journal that he puzzled all his life over the conundrum that “I both have a body while I am a body…having and being are twined around each other.”

The outstanding French philosopher Paul Ricœur (died in 2005) gives us a useful hint:

“To the extent that the body as my own constitutes one of the components of mineness, the most radical confrontation must place face-to-face two perspectives on the body—the body as mine, and the body as one body among others.  The reductionist thesis in this sense marks the reduction of one’s own body to the body as impersonal body.

“The brain indeed differs from many other parts of the body, and from the body as a whole in terms of an integral experience, inasmuch as it is stripped of any phenomenological status and thus of the trait of belonging to me, of being my possession.  I have the experience of my relation to my members as organs of movement (my hands), of perception (my eyes), of emotion (the heart), or of expression (my voice).  I have no such experience of my brain. In truth, the expression ‘my brain’ has no meaning, at least not directly: absolutely speaking, there is a brain in my skull, but I do not feel it. It is only through the global detour by way of my body, inasmuch as my body is also a body and as the brain is contained in this body, that I can say ‘my brain.’

“The unsettling nature of this expression is reinforced by the fact that the brain does not fall under the category of objects perceived at a distance from one’s own body. Its proximity in my head gives it the strange character of non-experienced interiority.  Mental phenomena pose a comparable problem.”

(Paul Ricœur, Oneself as Other, University of Chicago Press, 1994, page 132)

In other words, the removal of brain tumors such as glioblastomas or the alleviation of migraine headaches in headache clinics is one level of activity and is perfectly valid and neuro-scientific. On the other hand, the relation between brain, mind, body and self is a complete mystery as sensed by Gabriel Marcel and Ricœur.  It is not mechanistic and we lack the language to captures such resonances.

Money and funding and prestige and their relationship to science keep obscuring the deeper truths.  This is also why excellent TV shows on PBS, such as the recent The Brain Series with Charlie Rose, led by the marvelous Professor Eric Kandel (Columbia University Nobelist) comes across as overly narrow—too narrow and curiously unsatisfying.  At a certain point, ‘mechanistic’ descriptions of phenomena like creativity are not convincing.

The education we visualize and promote here would happily straddle neuroscience and those levels of understanding that are beyond it.

Essay 49: Postdicting the 2008 Great Recession: Macro and Finance

Prof. George Akerlof (2001 Nobel) shows how macroeconomics overlooked the issue of financial stability as a pillar. He argues that Rajan’s 2005 paper and talk were uniquely prescient on this.

This is why we find thinking about, say, the Panic of 1873 so instructive especially when one adds an “omnidirectional” analysis: In 1873, we get Around the World in Eighty Days with the transport revolutions that make winning this bet about circling the world in eighty days, at all possible: railroads, steamships, etc.  London is shown to have emerged as the world money center, as described in Walter Bagehot’s classic Lombard Street. The opening line of The Magnificent Ambersons is (in paraphrase):  “The financial crisis of 1873 destroyed the fortunes of most people but made the Ambersons and this was the basis of their magnificence.”

The novel The Age of Innocence by Edith Wharton, set in the 1870s, shows the financial shocks of 1873 as a major player in the story.

Prof. Adam Tooze of Columbia published in 2018 a masterful account of finance and macro and politics relevant to our 2008 fiasco in his Crashed:

Crashed:  How a Decade of Financial Crises Changed the World

Hence Akerlof’s depiction, in the current Journal of Economic Perspectives, of how macroeconomics became separated from financial instability analyses is key:

“The Keynesian–neoclassical synthesis that had emerged by the early 1960s put constraints on macroeconomics. Foremost, it divorced macroeconomists from working on financial stability.  Luckily, after the crash of 2008, the prior work of finance economists has been belatedly acknowledged, and the subfield of macro stability has also emerged as quite possibly the most vibrant research frontier in economics.  Nevertheless, macroprudential concerns remain as back matter in the textbooks.  Correspondingly, macroprudential policy is undervalued in the councils of government.  Yet its importance remains, given the likelihood of another crash.”

In this context, little damage could be done by macro models lacking the details of the financial system.  But exclusion of such detail (with the attendant possibility of financial crash) from standard macroeconomics could be a problem in a different context: if the financial system changed in fundamental ways.  That was exactly the topic of Rajan’s (2005) Jackson Hole talk, “Has Financial Development Made the World Riskier?” [PDF] which did predict the crash of 2008 as it actually happened.  In terms of the skeletal model, had that “financial development” beyond a well-supervised banking system with deposit insurance driven the financial system out of the safe region of always hold?  In September 2008, the answer to Rajan’s question became clear: “yes, it had.” 

Journal of Economic Perspectives—Volume 33, Number 4—Fall 2019—Pages 171–186

What They Were Thinking Then: The Consequences for Macroeconomics during the Past 60 Years [PDF] by Prof. George Akerlof.