Chance and Necessity

If you free-associate the word “chance,” you may arrive at “I’ll take my chances” before potentially arriving at Thomas Bayes’ “Doctrine of Chances”. Jacques Monod was an early explorer of the collision of probability and chance in biology.

THE PRINCE OF CHANCE

Jacques Monod grew up just down the coast from Monte Carlo in Cannes, France, another town famous for its casinos and, later, its film festival. Graced with movie star looks—one prominent French journalist described him as a “prince” who resembled Hollywood icon Henry Fonda, as well as considerable musical talent, and an exceptional intellect, Monod struggled to decide on a career path through his twenties. After distinguishing himself in the French Resistance, Monod rose to fame not as an actor or musician, but as a brilliant biologist. He shared the 1965 Nobel Prize in Physiology or Medicine for seminal discoveries about how genes work.

A pioneer in the field of molecular biology, Monod was privy to the blizzard of discoveries in the 1950s and early 1960s about the molecules that determined the characteristics of living things—what Monod and others dubbed “the secrets of life.” He kept close company with a relatively small international community of leading researchers. For example, when James Watson and Francis Crick cracked the structure of DNA (deoxyribonucleic acid) in 1953, Monod was one of the first with whom Watson shared the breakthrough.

But as a Frenchman steeped in his culture’s deep philosophical traditions, Monod was interested in science for more than just science’s sake. After the war, Monod befriended France’s leading philosopher-writer Albert Camus, and the two men pondered questions of human existence in Left Bank cafés. Monod felt that the public misunderstood the principal purpose of science as being the creation of technology. Rather, Monod believed technology was merely a by-product. He said, “the most important results of science have been to change the relationship of man to the universe, or the way he sees himself in the universe”—a relationship of equally intense interest to his friend Camus.

Monod thought that there were profound philosophical implications of the new molecular biology, particularly in the realm of heredity, which had gone largely unnoted in the broader culture. Several years after his Nobel Prize and Camus’ untimely death, he decided to write a book to try to bring the meaning of modern biology to laypersons.

“[T]he ‘secret of life’…has been laid bare,” he wrote.

“This, a considerable event, ought certainly to make itself strongly felt in contemporary thinking.”

Monod used several chapters to describe the insights that had very recently emerged from the study of DNA and the deciphering of the genetic code. He understood this knowledge would be unfamiliar to most readers, so he included an appendix with chemical structures of proteins and nucleic acids, and a primer on how the genetic code worked.

In a matter-of-fact style, he explained genetic mutations as accidental alterations—substitutions, additions, deletions, or rearrangements—in the text of DNA, in the sequence of the long strings of chemical bases (ACTTGATAA, etc.) that make up genes.

Then, almost without warning, he turned to the broader implications of how mutations arise in DNA. It is worth quoting him at length for after 111 pages of background, he delivered one of the most powerful ideas in five centuries of science (all italics are original):

“We call these events accidental; we say they are random occurrences. And since they constitute the only possible source of modifications in the genetic text, itself the sole repository of the organism’s hereditary structure, it necessarily follows that chance alone is at the source of every innovation, of all creation in the biosphere.

“Pure chance, absolutely free but blind, at the very root of the stupendous edifice of evolution: this central concept of modern biology is no longer one among other possible or even conceivable hypotheses. It is today the sole conceivable hypothesis, the only one that squares with observed and tested fact. And nothing warrants the supposition—or the hope—that on this score our position is likely ever to be revised.

“There is no scientific concept, in any of the sciences, more destructive of anthropocentrism than this one.”

In essence, heretofore obscure discoveries in biochemistry and genetics (largely studied at that time in simple bacteria) had upended two millennia of philosophy and religion that put humans at the center or apex of creation. “Man was the product of an incalculable number of fortuitous events,” Monod wrote. “The result of a huge Monte Carlo game, where our number eventually did come out, when it might not well have appeared.”

Le Hasard et la nécessité (Chance and Necessity) appeared in France in October 1970. It was a fairly technical book with several chapters on philosophy and genetics, and those appendices full of chemical diagrams. A first-time author, Monod did not know what reactions to expect.

The merde hit the fan.

The book received dozens of reviews across France and quickly became a bestseller—second only to the French translation of Erich Segal’s Love Story (this was France after all. After it was translated into English, reviews and interviews with Monod were featured in several of the most prominent British and American newspapers and magazines.

Many commentators immediately recognized the threat chance posed to traditional ideas of humanity’s origins and purpose. To Arthur Peacocke, a British biochemist turned prominent theologian, Monod had put forth “one of the strongest and most influential attacks of the century on theism.” A flurry of articles and books appeared with titles such as Anti-Chance: A Reply to Monod’s Chance and Necessity, Beyond Chance and Necessity, and God, Chance, and Necessity. Monod was invited to debate philosophers and theologians both in France and abroad, on television, radio, and in print.

American Calvinist theologian and pastor R.C. Sproul summed up the high stakes posed by chance in the first page of his book Not A Chance:

“It is not necessary for chance to rule in order to supplant God. Indeed, chance requires little authority at all if it is to depose God; all it needs to do the job is to exist. The mere existence of chance is enough to rip God from his cosmic throne. Chance does not need to rule; it does not need to be sovereign. If it exists as a mere impotent, humble servant, it leaves God not only out of date, but out of a job.” More than two hundred pages later, Sproul concluded:

“Chance as a real force is a myth. It has no basis in reality and no place in scientific inquiry. For science and philosophy to continue to advance in knowledge, chance must be demythologized once and for all.”

Sproul and other critics argued that what scientists perceived as chance merely reflected a lack of knowledge of true causes. Perhaps that was the expression of hope to which Monod alluded—the hope that as scientists learned more, our position on the role of chance would somehow be revised.

A SECOND CHANCE

The ensuing fifty years have not played out as either Monod or his detractors hoped. The Frenchman thought that the new insights from molecular biology should be a turning point for modern society-away from traditional beliefs about causes in the natural world toward one that embraced randomness and our chance existence.

Ha! Fat chance. The excitement and fuss stirred by Chance and Necessity simmered down, and Monod passed away a few years later. Surveys reveal that the majority of Americans, for example, continue to believe that everything on earth happens for His reasons.

But Monod’s critics should take no comfort. The province of chance in the biosphere and human life has been revised, although not at all in the scope or direction that they hoped.

The domain of chance has expanded into realms neither Monod nor anyone else imagined.

As we have learned much more about the history and workings of the planet, we have been startled to discover how the course of life has been buffeted by a variety of cosmological and geological accidents—without which we would not be here. As we have explored human history, we have seen how pandemics, droughts, and other civilization-changing episodes have been triggered by random, singular events in nature that easily might not have happened. And as we have probed human biology and the factors that impact our individual lives, we have caught chance red-handed, reigning over the often-thin line between life and death.

This book tells the stories that Monod could not—of astonishing discoveries from the planetary to the molecular scale, from great upheavals across the globe to the machinery of chance that operates within every cell of every creature, including ourselves. And while these discoveries vaporize the comforts of anthropocentrism, the story of chance, I hope you will come to agree, is much more than highfalutin philosophy or the refutation of theologians’ wishful thinking.

I hope that you are awed—awed by the power and the drama of asteroids slamming into the planet, of continents colliding, and of the rapid rising and falling of ice and oceans; awed by the realization that we live on (and are at the mercy of a planet that is far more unstable than our short lives perceive; awed by the knowledge of how random chance is at the source of all of the beautiful and wondrous creatures with whom we share the planet; awed by the unique invisible accidents that made each one of us; and awed by the fact that we humans, recent descendants of bands of hunter-gatherers who persevered through a period of exceptional chaos, have in just the last fifty years or so, figured all of this out!

My goal here is to be comprehensible without being comprehensive. It is almost trivial to claim that the world is the way it is or that we are here because of a long chain of chance, albeit fortunate, events. The explanatory power I seek comes from specificity. It is essential to unpack some of those events to appreciate how they shape the direction of life. The layout of the book follows a simple three-part logic. I’ll begin with inanimate, external chance events that have shaped the conditions for life (Part One, “Stuff Happens”), and then turn to the internal random mechanism within every creature that generates the adaptations to those conditions (Part Two, “A World of Mistakes”). Then, I bring the story to the personal level (Part Three, “23 and You”) and how chance impacts our natural lives, as well as our deaths. Our chance-driven existence shatters long-held beliefs about humanity’s place and raises challenging questions about the meaning and purpose of our lives. In the Afterword, I’ll offer some possible replies with the help of some special guests.

This is a relatively small book for a really big idea. Science has given us a handful of really big ideas over the centuries, but they have been received in funny ways. Darwin had a huge idea that was very simple to understand, and even though the evidence is massive and everywhere, many refuse to believe it. Einstein had a brand new idea, and even though few understand it or the evidence for it, most everyone seems to believe it. Monod had a great idea, but these days most people (other than scholars) have not heard of it, or of him.

My greatest hope, then, is that this short book might be chance’s second chance.

Sean B. Carroll, A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You, Princeton University Press, 2020, pp. 6-12.

Modern biology as described by Monod pushes the linkage of probability, randomness and chance to the center. At the time, this was a very radical and profound way of looking at biology. If we combine Monod’s biology with theoretical physics like Lawrence Krauss’ A Universe from Nothing: Why There Is Something Rather than Nothing, we realize that accidentality is the bedrock on which our knowledge of the universe is built.

Songs and Tweaking Our Understanding, Part 2

Let’s look at three songs: “Cabaret” (from the musical of the same title), “Is That All There Is?” and “More Than a Woman” by the Bee Gees.

In “Cabaret” the character Sally Bowles sings, “Start by admitting from cradle to tomb / It isn’t that long a stay / Life is a cabaret, old chum…” She asserts that life is so short that one shouldn’t take it seriously and should be treated as boisterous fun.

Earlier, she sang:

I used to have this girlfriend known as Elsie
With whom I shared four sordid rooms in Chelsea
She wasn’t what you’d call a blushing flower
As a matter of fact, she rented by the hour

The day she died the neighbors came to snicker:
“Well, that’s what comes from too much pills and liquor”
But when I saw her laid out like a queen
She was the happiest corpse I’d ever seen

Does the idea of a happy corpse ring true? As a corollary of this, is it plausible that a smile survives hours after death?

While “Cabaret” compares life to the titular cabaret, there are many other songs with simplified comparisons of life, none of which cover the full breadth of human experience. The French philosopher Maurice Merleau-Ponty wrote that the world is inexhaustible, and to extend this, so too is life.

In “Is That All There Is?” each question has several levels. When confronted with the fire that claims her childhood home, the disappointment of the circus and finally the loss of her love, the song echoes “Cabaret” with the chorus:

Is that all there is?
If that’s all there is my friends, then let’s keep dancing
Let’s break out the booze and have a ball

Much like the way “Cabaret” repeats “Life is a cabaret, old chum / Come to the cabaret”.

In “More Than a Woman” by the Bee Gees, they sing, “We can take forever, just a minute at a time”. Can we visualize this in the concrete terms of the song? In Western tradition, we often associate the search for forever with young love. What does it mean to fuse the momentary and the forever?

The Bee Gees song gives us an entry to the changing sense of time experienced by a living person, as contrasted to the objective time of a fossil carbon-dated by a paleontologist.

Existence and the Problem of Separability

In contracts and legal documents, there is a concept of “separability” which means that clause A is connected to clause B in a way that cannot be undone.

The great twentieth century French philosopher, Gabriel Marcel, has a profound non-separability analysis of existence itself. Marcel wrote:

…We cannot really separate:—

  1. Existence
  2. Consciousness of self as existing
  3. Consciousness of self as bound to a body, as incarnate.
Gabriel Marcel, Being and Having: An Existentialist Diary, Harper Torchbooks, 1965, page 10.

This leads to saying things that are very deep aspects of existential thinking governed by the points above. For example, Marcel wrote, “As I have said elsewhere, the moment I treat my body as an object of scientific knowledge, I banish myself to infinity.” Consider the end of the previous phrase. The very notion that someone, within themselves could go down a route to “banish themselves” in this way, shows you a door into very deep psychological problems. In other words, Marcel is telling you that some psychological problems could have a philosophical or existential root cause and are a type of blunder.

This is not to say that one should avoid scientific thought. Taking a drop of your blood and viewing it under a microscope is not a blunder. However, if you take this to the extreme of trying to analyze everything scientifically, to the exclusion of philosophy in daily life, this is Marcel’s warning.

Marcel’s context for this thinking is given here:

Notes for a Paper to the Philosophical Society

Undated, written in 1927 or 19281

When I affirm that something exists, I always mean that I consider this something as connected with my body, as able to be put in contact with it, however indirect this contact may be. But note must be taken that the priority I thus ascribe to my body depends on the fact that my body is given to me in a way that is not exclusively objective, i.e. on the fact that it is my body. This character, at once mysterious and intimate, of the bond between me and my body (I purposely avoid the word relation) does in fact colour all existential judgments.


What it comes to is this. We cannot really separate:—

  1. Existence
  2. Consciousness of self as existing
  3. Consciousness of self as bound to a body, as incarnate.

From this several important conclusions would seem to follow:

  1. In the first place, the existential point of view about reality cannot, it seems, be other than that of an incarnate personality. In so far as we can imagine a pure understanding, there is, for such an understanding, no possibility of considering things as existent or non-existent.
  2. On the one hand, the problem of the existence of the external world is now changed and perhaps even loses its meaning; I cannot in fact without contradiction think of my body as non-existent, since it is in connection with it (in so far as it is my body) that every existing thing is defined and placed. On the other hand, we ought to ask whether there are valid reasons for giving my body a privileged metaphysical status in comparison with other things.
  3. If this is so, it is permissible to ask whether the union of the soul and body is, in essence, really different from the union between the soul and other existing things. In other words, does not a certain experience of the self, as tied up with the universe, underlie all affirmation of existence?
  4. Inquire whether such an interpretation of the existential leads towards subjectivism.
  5. Shew how idealism tends inevitably to eliminate all existential considerations in view of the fundamental unintelligibility of existence. Idealism versus metaphysics. Values detached from existence: too real to exist.

Existential and personalist interests closely linked. The problem of the immortality of the soul is the pivot of metaphysic.

Every existent is thought of like an obstacle by which we take our bearings—like something we could collide with in certain circumstances—resistent, impenetrable. We think of this impenetrability, no doubt, but we think of it as not completely thinkable.2 Just as my body is thought of in so far as it is a body, but my thought collides with the fact that it is my body.

To say that something exists is not only to say that it belongs to the same system as my body (that it is bound to it by certain connections which reason can define), it is also to say that it is in some way united to me as my body is.

Incarnation—the central ‘given’ of metaphysic. Incarnation is the situation of a being who appears to himself to be, as it were, bound to a body. This ‘given’ is opaque to itself: opposition to the cogito. Of this body, I can neither say that it is I, nor that it is not I, nor that it is for me (object). The opposition of subject and object is found to be transcended from the start. Inversely, if I start from the opposition, treating it as fundamental, I shall find no trick of logical sleight of hand which lets me get back to the original experience, which will inevitably be either eluded or (which comes to the same thing) refused. We are not to object that this experience shews a contingent character: in point of fact, all metaphysical enquiry requires a starting-point of this kind. It can only start from a situation which is mirrored but cannot be understood.

Inquire if incarnation is a fact; it does not seem so to me, it is the ‘given’ starting from which a fact is possible (which is not true of the cogito).

A fundamental predicament which cannot be in a strict sense mastered or analysed. It is exactly this impossibility which is being stated when I declare, confusedly, that I am my body; i.e. I cannot quite treat myself as a term distinct from my body, a term which would be in a definable connection with it. As I have said else-where, the moment I treat my body as an object of scientific know-ledge, I banish myself to infinity.

This is the reason why I cannot think of my death, but only of the standstill of that machine (illam, not banc). It would perhaps be more accurate to say that I cannot anticipate my death, that is, I cannot ask myself what will become of me when the machine is no longer working.3

[1] This paper was never delivered.

[2] It is thought of, but it is never resolved. The opacity of the world is in a certain sense insoluble. The link between opacity and Meinbeit. My idea is opaque to me personally in so far as it is mine. We think of it as an adherence. (Note written Feb. 24th, 1929.)

[3] ‘To be involved.’ (idée d’un engagement) Try to shew in what sense this implies the impossibility (or absolute non-validity of my representing my death. In trying to think of my death I break the rules of the game. But it is radically illegitimate to convert this impossibility into a dogmatic negation. (Note written Feb. 24th, 1929.)

It is evident that this whole train of thought is at the root of le Gouvernail: the first notes on the theme of le Gouvernail were composed a few days after these. (Note written April 13th, 1934.)

Gabriel Marcel, Being and Having: An Existentialist Diary, pages 10-12

The reader should not be afraid of converting this level of discussion to everyday life and everyday slang. For example, when Marcel uses phrases like, “I banish myself to infinity” that should resonate with phrases like “flipping out.”

Take this example from Kierkegaard. There’s a book-seller in Copenhagen and he greets a customer who has just entered his shop. The book-seller turns to his wife and says, “It is I who am speaking, isn’t it?” Kierkegaard’s book-seller seems to have “banished himself” and cannot return.

Problems of Perspective, Michel Foucault

Michel Foucault was one of the leading French philosophers of the 20th century. Often considered a postmodernist, he did not believe there was a final perspective that human knowledge could achieve. This immediately contrasts with the outlook of leading physicists like Stephen Hawking. In his 1988 classic, A Brief History of Time, Hawking concludes the book by saying, once science has achieved a theory of everything, which is not far off, we will “know the mind of god.”

In his 1966 key work, The Order of Things: An Archaeology of the Human Sciences (French: Les Mots et les Choses: Une archéologie des sciences humaines), Foucault argued that the so-called order of things is invented, not discovered, by us. This is contrary to scientific thought.

Foucault sets up this limit in his surprising interpretation of the Diego Velázquez masterpiece painting, Las Meninas (Spanish: The Ladies-in-waiting). The painting is deliberately elusive in its use of perspective.

The great German thinker, Jürgen Habermas, explained this Foucault/Velázquez perspective difficulty:

This picture portrays the painter in front of a canvas not visible to the spectator; the painter is evidently looking, as are the two ladies-in-waiting next to him, in the direction of his two models, King Philip IV and his spouse. These two personages standing as models are found outside the frame of the picture; they can be identified by the spectator only with the help of a mirror pictured in the background. The point that Velázquez apparently had in mind is a confusing circumstance of which the spectator becomes aware by inference: The spectator cannot avoid assuming the place and the direction of the gaze of the counterfeit but absent royal pair — toward which the painter captured in the picture gazes — as well as the place and the perspective of Velázquez himself, which is to say, of the .painter who actually produced this picture. For Foucault, in turn, the real point lies in the fact that the classical picture frame is too limited to permit the representation of the act of representing as such — it is this that Velázquez makes clear by showing the gaps within the classical picture frame. left by the lack of reflection on the process of representing itself.29

29. Foucault constructs two different series of absences. On the one hand, the painter in the picture lacks his model, the royal couple standing outside the frame of the picture; the latter are in turn unable to see the picture of themselves that is being painted — they only see the canvas from behind; finally, the spec­tator is missing the center of the scene, that is, the couple standing as models, to which the gaze of the painter and of the courtesans merely directs us. Still more revealing than the absence of the objects being represented is, on the other hand, that of the subjects doing the representing, which is to say, the triple absence of the painter, the model, and the spectator who, located in front of the picture, takes in perspectives of the two others. The painter, Velázquez, actually enters into the picture, but he is not presented exactly in the act of painting — one sees him during a pause and realizes that he will disappear behind the canvas as soon as he takes up his labors again. The faces of the two models can actually be recognized unclearly in a mirror reflection, but they are not to be observed directly during the act of their portrayal. Finally, the act of the spectator is equally unrepresented — the spectator depicted entering into the picture from the right cannot take over this function. (See Foucault, The Order of Things, pp. 3-16, 307-311.)

Critique and Power: Recasting the Foucault/Habermas Debate, Michael Kelly, editor, MIT Press, 1994, pages 67, 77 [archived PDF].

Let us conclude by saying one way of specifying the disagreement between scientists and these thinkers is that sciences see themselves as “objective” while the thinkers feel science lacks objectivity because of the human observer. Kant, centuries ago, argued that concepts like causality, space and time are imposed by the human mind on the world. Similarly, Heisenberg, in Physics and Philosophy: The Revolution in Modern Science, similarly said that science does not finally answer questions about an objective reality, but can only answer questions posed by us.